Gene Report

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Basic Info

Approved Symbol	NDUFA4
Symbol Alias	MLRQ, CI-9k
Approved Name	NDUFA4, mitochondrial complex associated
Previous Name	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4 (9kD, MLRQ), "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa"
Name Alias	complex I 9kDa subunit, "NADH-ubiquinone oxidoreductase MLRQ subunit"
Location	7p21.3
Position	chr7:10931951-10940256, -1
External Links	HGNC: 7687 Entrez Gene: 4697 Ensembl: ENSG00000189043 UCSC: uc003srx.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Winham S.J., 2014	SNP: rs10224816	It showed little evidence for association with BD.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005747	mitochondrial respiratory chain complex I	cellular component	IDA[12611891]; IDA[22902835]; NAS[9878551]	2
GO:0005739	mitochondrion	cellular component	IDA[16729965]	75
GO:0005743	mitochondrial inner membrane	cellular component	TAS	12
GO:0004129	cytochrome-c oxidase activity	molecular function	IMP[22902835]	2
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0032403	protein complex binding	molecular function	IDA[23209302]	16
GO:0005515	protein binding	molecular function	IPI[19822128]	563
GO:0005751	mitochondrial respiratory chain complex IV	cellular component	IDA[22902835]	1
GO:0044237	cellular metabolic process	biological process	TAS	3
GO:0008137	NADH dehydrogenase (ubiquinone) activity	molecular function	NAS[9878551]	2
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	biological process	NAS[9878551]	3
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:1902600	hydrogen ion transmembrane transport	biological process	IMP[22902835]	4
GO:0022904	respiratory electron transport chain	biological process	TAS	3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00190	Oxidative phosphorylation	7

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10224816	chr7:9672029 - 9672029(1)		1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7p22.2-p21.1	chr7:2800000-20900000	1 (0/0/1)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p21.3	chr7:7200000-13700000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:10931951..10940256 View in gBrowse