Gene Report

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Basic Info

Approved Symbol	PRR5
Symbol Alias	PP610, FLJ20185k, Protor-1
Approved Name	proline rich 5 (renal)
Name Alias	protein observed with Rictor-1
Location	22q13.3
Position	chr22:44668547-44737681, 1
External Links	HGNC: 31682 Entrez Gene: 55615 Ensembl: ENSG00000186654
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Winham S.J., 2014	SNP: rs6006893	rs6006893 in PRR5 showed little evidence for association with BD.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0031932	TORC2 complex	cellular component	IDA[22609986]	2
GO:0007049	cell cycle	biological process	IEA	6
GO:0001934	positive regulation of protein phosphorylation	biological process	IEA	15
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	biological process	IEA	9

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6006893	chr22:44858015 - 44858015(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q12.3-13.32	chr22:31800000-49100000	1 (0/1/0)
Chr 22	chr22:0-50818468	2 (0/1/1)
22q12.3-q13.33	chr22:31800000-50818468	1 (1/0/0)
22q13	chr22:37200000-50818468	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr22:44668547..44737681 View in gBrowse