BDgene

SNP Report

Basic Info
Name rs933151 dbSNP Ensembl
Location chr21:44416122 - 44416122(1)
Variant Alleles C/T
Ancestral Allele T
Minor Allele C
Minor Allele Frequence 0.265974
Functional Annotation intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant.
Consequence to Transcript intron_variant(ENST00000300481, ENST00000300482, ENST00000397928, ENST00000397932, ENST00000423310, ENST00000498430); non_coding_transcript_exon_variant(ENST00000456880); non_coding_transcript_variant(ENST00000423310, ENST00000456880, ENST00000498430)
No. of Studies 4 (Positive: 1; Negative: 3; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 4)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Roche, S., 2007 TDT allelic P-value = 0.592, X9=0.287 TDT allelic P-value = 0.592, X9=0.287 There was no evidence for association in the single-marker a...... There was no evidence for association in the single-marker association analyses More... Negative
Xu, C.,2009 C TDT: in BD families, X2=0.04, P-value = 0.846; in...... TDT: in BD families, X2=0.04, P-value = 0.846; in BD-I families, X2=0.01, P-value = 0.935; in BD-II families, X2=0.46, P-value = 0.499 More... No significant association was observed No significant association was observed Negative
Xu, C., 2006 T/C allelic P-value = 0.002, corrected P-value = 0.011, X2<...... allelic P-value = 0.002, corrected P-value = 0.011, X2=10.13, genotypic P-value = 0.003, corrected P-value = 0.063, X2=11.47 in BD; allelic P-value = 0.008, corrected P-value = 0.055, X2=7.09, genotypic P-value = 0.02, X2=7.8 in BD-I; allelic P-value = 0.014, X2=6.11, genotypic P-value = 0.003, corrected P-value = 0.042, X2=11.97 in BD-II More... Positive
McQuillin, A., 2006 P-value = 0.331, Pearson's X2=0.944 P-value = 0.331, Pearson's X2=0.944 Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
TRPM2 transient receptor potential cation channel, subfamily M, member 2 21q22.3 5(3/2/0)

SNPs in LD with rs933151 (count: 9) View in gBrowse (chr21:44398726..44420722 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 9)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)