BDgene

SNP Report

Basic Info
Name rs1618355 dbSNP Ensembl
Location chr21:44406579 - 44406579(1)
Variant Alleles C/A/G
Ancestral Allele C
Minor Allele C
Minor Allele Frequence 0.323482
Functional Annotation intron_variant; non_coding_transcript_variant.
Consequence to Transcript intron_variant(ENST00000300481, ENST00000300482, ENST00000397928, ENST00000397932, ENST00000498430); non_coding_transcript_variant(ENST00000498430)
No. of Studies 3 (Positive: 1; Negative: 2; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Xu, C., 2006 A/C allelic P-value < 0.00001, corrected P-value < 7.0E-5 , X allelic P-value < 0.00001, corrected P-value < 7.0E-5 , X2=41.77, genotypic P-value = 1.20E-09, corrected P-value = 2.0E-08, X2=41.05 in BD; allelic P-value < 0.00001, corrected P-value < 7.0E-05 , X2=30.97, genotypic P-value = 1.5E-07, corrected P-value = 3.0E-06, X2=31.44 in BD-I; allelic P-value = 0.00001, corrected P-value < 7.0E-05 , X2=24.45, genotypic P-value = 2.6E-07, corrected P-value = 3.6E-06 , X2=30.35 in BD-II More... Statistically significant increased allele 2 (minor allele) ...... Statistically significant increased allele 2 (minor allele) frequencies were observed for intron 18 and 19 SNPs in BD as compared with those in healthy controls. Moreover, the allele 2 frequencies of intron 18 and intron 19 SNPs were also significantly increased in both BD-I and BD-II patient groups as compared with controls. More... Positive
McQuillin, A., 2006 P-value = 0.427, Pearson's X2=0.63 P-value = 0.427, Pearson's X2=0.63 Negative
Xu, C.,2009 C TDT: in BD families, X2=0.2, P-value = 0.653; in ...... TDT: in BD families, X2=0.2, P-value = 0.653; in BD-I families, X2=0.08, P-value = 0.782; in BD-II families, X2=2.33, P-value = 0.127 More... No significant association was observed No significant association was observed Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
TRPM2 transient receptor potential cation channel, subfamily M, member 2 21q22.3 5(3/2/0)

SNPs in LD with rs1618355 (count: 0) View in gBrowse (chr21:44406579..44406579 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)