BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Lyons-Warren, A.,2005 PMID: 15983625
Citation	Lyons-Warren, A., J. J. Chang, et al. (2005). Evidence of association between bipolar disorder and Citron on chromosome 12q24. Mol Psychiatry 10(9): 807-809.
Disease Type	Bipolar Disorder
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	307 nuclear families consisting of 1012 individuals,including probands diagnosed with BPI, BPII,schizoaffective disorder, or unipolar depression
SNP/Region/Marker Size	7 SNPs
Predominant Ethnicity
Population	NIMH collections(wave 3 and wave 4 pedigrees )

Detail Info

SNPs reported by this study for BD (count: 2)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs435136	CIT	T/C		FBAT: P-value = 0.012	Significant associations were found . Significant associations were found .	Positive
rs203368	CIT	G/A		FBAT: P-value = 0.020	Significant associations were found . Significant associations were found .	Positive

Haplotypes reported by this study for BD (count: 11)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs435136 - hCV3259834	C-G	CIT	Haplotypic association:FBAT, under-transmitted, individual P-value = 0.026	Significant association was found in individual P-value. Significant association was found in individual P-value.	Positive
rs278124 - rs278109 - rs203368 - rs435136	C-G-A-C	CIT	Haplotypic association:FBAT, under-transmitted, individual P-value = 0.026	Significant association was found in individual P-value. Significant association was found in individual P-value.	Positive
rs435136 - hCV3259834	T-A	CIT	Haplotypic association:FBAT, over-transmitted, individual P-value = 0.044	Significant association was found in individual P-value. Significant association was found in individual P-value.	Positive
rs278109 - rs203368	G-A	CIT	Haplotypic association:FBAT, under-transmitted, individual P-value = 0.049	Significant association was found in individual P-value. Significant association was found in individual P-value.	Positive
rs2285595 - rs278109 - rs203368 - rs435136 - hCV3259834	T-A-G-T-A	CIT	Haplotypic association:FBAT, over-transmitted, individual P-value = 0.053	No significant association was found . No significant association was found .	Negative
rs278124 - rs278109 - rs203368	C-G-A	CIT	Haplotypic association:FBAT, under-transmitted, individual P-value = 0.03	Significant association was found in individual P-value. Significant association was found in individual P-value.	Positive
rs278109 - rs203368 - rs435136 - hCV3259834	A-G-T-A	CIT	Haplotypic association:FBAT, over-transmitted, individual P-value = 0.065	No significant association was found . No significant association was found .	Negative
rs203368 - rs435136	G-T	CIT	Haplotypic association:FBAT, over-transmitted, individual P-value = 0.011	Significant association was found in individual P-value. Significant association was found in individual P-value.	Positive
rs203368 - rs435136	A-C	CIT	Haplotypic association:FBAT, under-transmitted, individual P-value = 0.014	Significant association was found in individual P-value. Significant association was found in individual P-value.	Positive
rs203368 - rs435136 - hCV3259834	G-T-A	CIT	Haplotypic association:FBAT, over-transmitted, individual P-value = 0.031	Significant association was found in individual P-value. Significant association was found in individual P-value.	Positive
rs203368 - rs435136 - hCV3259834	A-C-G	CIT	Haplotypic association:FBAT, under-transmitted, individual P-value = 0.041	Significant association was found in individual P-value. Significant association was found in individual P-value.	Positive

Genes reported by this study for BD (count: 1)