Study Report

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Basic Info

Reference	Leszczynska-Rodziewicz A, 2013 PMID: 23068076
Citation	Leszczynska-Rodziewicz, A., A. Szczepankiewicz, et al. (2013). "No association between polymorphisms and haplotypes of the AVPR1b, CRHR1 and NR3C1 genes and depression with melancholic features in the course of bipolar disorder." Psychiatry Res 207(1-2): 140-142.
Disease Type	bipolar disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	130 patients with melancholic depression in the course of bipolar type I(BPI) disorder and 712 healthy controls
SNP/Region/Marker Size	21 SNPs
Predominant Ethnicity	Caucasian
Population	Polish
Gender	39 males and 91 females of cases, 301 males and 411 females of controls
Age Group	children and adults : 1-54 years, mean=15 years,S.D.=11 of cases

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	The study was performed on a group of 130 patients with melancholic depression in the course of bipolar type I(BPI) disorder (39 males and 91 females) from the total group of 514 BPI patients who were living in the Wielkopolska region of Poland. Patients were recruited from inpatients,treated at the Department of Adult Psychiatry, Poznan University of Medical Sciences. Diagnosis was done based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria of melancholic depression. The diagnosis was established using the Structured Clinical Interview for DSM-IV Axis I Disorders(SCID-I). The Controls were blood donors, but only 40% of them were psychiatrically screened.
Technique	not mentioned in this article
Statistical Method	not mentioned in this article
Result Summary	The present study included 130 patients with melancholic depression in the course of bipolar disorder and 732 healthy controls. No association was found for alleles, genotypes, or haplotype analysis for NR3C1, AVPR1b, and CRHR1 genes and melancholic depression.

SNPs reported by this study for BD (count: 21)

SNP	Related Gene(s)	Allele Change	Statistical Values	Author Comments	Result Category
rs41423247	NR3C1	C/G	P-value=0.2	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs56149945	NR3C1	C/T	P-value=0.37	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs10052957	NR3C1	A/G	P-value=0.22	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs6198	NR3C1	C/T	P-value=0.65	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs6191	NR3C1	A/C	P-value=0.26	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs258813	NR3C1	A/G	P-value=0.17	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs6196	NR3C1	A/G	P-value=0.27	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs33388	NR3C1	A/T	P-value=0.23	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs28536160	AVPR1B	C/T	P-value=0.30	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs28373064	AVPR1B	A/G	P-value=0.13	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs12936511	CRHR1 MAPT-AS1	C/T	P-value=0.40	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs4076452	CRHR1	C/G	P-value=0.60	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs28632197	AVPR1B	A/G	P-value=0.43	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs35369693	AVPR1B	C/G	P-value=0.87	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs173365	CRHR1 MAPT-AS1	A/G	P-value=0.60	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs878886	CRHR1 MAPT-AS1	C/G	P-value=0.50	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs242950	CRHR1 MAPT-AS1	C/T	P-value=0.90	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs4792887	CRHR1 MAPT-AS1	C/T	P-value=0.90	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs1694065	ARL15 CRHR1	C/T	P-value=0.20	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs110402	CRHR1 MAPT-AS1	A/G	P-value=0.10	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative
rs242937	CRHR1 MAPT-AS1	A/G	P-value=0.40	Neither genotypes nor alleles were significantly associated ...... Neither genotypes nor alleles were significantly associated with melancholic depression. More...	Negative

Genes reported by this study for BD (count: 3)

Gene	Statistical Values/Author Comments	Result Category
NR3C1	In our study we found no association between melancholic depression and polymorphisms in this gene. In our study we found no association between melancholic depression and polymorphisms in this gene.	Negative
CRHR1	In our study we found no association between melancholic depression and polymorphisms in this gene. In our study we found no association between melancholic depression and polymorphisms in this gene.	Negative
AVPR1B	In our study we found no association between melancholic depression and polymorphisms in this gene. In our study we found no association between melancholic depression and polymorphisms in this gene.	Negative