Study Report
Basic Info
| Reference |
Forstner, A. J., 2015 PMID: 26556287
|
| Citation |
Forstner, A. J., et al. (2015). "Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder." Transl Psychiatry 5: e678.
|
| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Genome-wide association study |
| Sample Size |
9,747 patients, 14,278 controls |
| Predominant Ethnicity |
|
| Population |
Canada, Australia and four European countries (MooDS) |
Detail Info
| Sample Status |
The gene-based tests were performed using data from our previous GWAS of BD (9747 patients and 14 278 controls). This GWAS data set combined data from Canada, Australia and four European countries (MooDS) with the GWAS results of the multinational Psychiatric Genomics Consortium(PGC). |
| Technique |
Genome-wide miRNA association analysis, Follow-up of miRNA association results—regional association plots, Follow-up of miRNA association results—miRNA brain expression, miRNA target gene analysis, Pathway analysis of target genes, Functional analyses of miR-499 and miR-708 in rat hippocampal neurons. |
| Result Summary |
After correction for multiple testing, nine microRNAs showed a significant association with BD. The most promising were miR-499, miR-708 and miR-1908. Target gene and pathway analyses revealed 18 significant canonical pathways, including brain development and neuron projection. For miR-499, four Bonferroni-corrected significant target genes were identified, including the genome-wide risk gene for psychiatric disorder CACNB2. |
SNPs reported by this study for BD (count: 9)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs2965184 |
GATAD2A
MIR640
|
|
|
P-value=7.23E-7
|
After correction for multiple testing, nine miRNAs showed a ......
After correction for multiple testing, nine miRNAs showed a significant association with BD.
More...
|
Trend
|
| rs3818253 |
TRPC4AP
|
|
|
P-value=6.58E-7
|
After correction for multiple testing, nine miRNAs showed a ......
After correction for multiple testing, nine miRNAs showed a significant association with BD.
More...
|
Trend
|
| rs697112 |
ARL15
|
|
|
P-value=3.61E-6
|
After correction for multiple testing, nine miRNAs showed a ......
After correction for multiple testing, nine miRNAs showed a significant association with BD.
More...
|
Trend
|
| rs7108878 |
TENM4
|
|
|
P-value=3.45E-7
|
After correction for multiple testing, nine miRNAs showed a ......
After correction for multiple testing, nine miRNAs showed a significant association with BD.
More...
|
Trend
|
| rs9311474 |
|
|
|
P-value=2.16E-5
|
After correction for multiple testing, nine miRNAs showed a ......
After correction for multiple testing, nine miRNAs showed a significant association with BD.
More...
|
Negative
|
| rs7269526 |
ITCH
MIR644A
|
|
|
P-value=1.22E-5
|
After correction for multiple testing, nine miRNAs showed a ......
After correction for multiple testing, nine miRNAs showed a significant association with BD.
More...
|
Negative
|
| rs174575 |
FADS2
|
|
|
P-value=2.85E-5
|
After correction for multiple testing, nine miRNAs showed a ......
After correction for multiple testing, nine miRNAs showed a significant association with BD.
More...
|
Negative
|
| rs6445358 |
WDR82
|
|
|
P-value=2.23E-5
|
After correction for multiple testing, nine miRNAs showed a ......
After correction for multiple testing, nine miRNAs showed a significant association with BD.
More...
|
Negative
|
| rs174535 |
MYRF
TMEM258
|
|
|
P-value=5.03E-5
|
After correction for multiple testing, nine miRNAs showed a ......
After correction for multiple testing, nine miRNAs showed a significant association with BD.
More...
|
Negative
|
