SNP Report

Basic Info

Name	rs174535 dbSNP Ensembl
Location	chr11:61783884 - 61783884(1)
Variant Alleles	T/A/C/G
Ancestral Allele	C
Minor Allele	C
Minor Allele Frequence	0.340056
Functional Annotation	downstream_gene_variant; intron_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; synonymous_variant. Polyphen Annotation: probably damaging(ENST00000278836, ENST00000389602); possibly damaging(ENST00000265460) SIFT Annotation: tolerated(ENST00000265460, ENST00000389602); deleterious(ENST00000278836)
Consequence to Transcript	downstream_gene_variant(ENST00000536352, ENST00000537318, ENST00000546247); intron_variant(ENST00000535042); missense_variant(ENST00000265460, ENST00000278836, ENST00000389602); non_coding_transcript_exon_variant(ENST00000539361); non_coding_transcript_variant(ENST00000535042, ENST00000539361); synonymous_variant(ENST00000265460, ENST00000278836, ENST00000389602)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Forstner, A. J., 2015			P-value=5.03E-5 P-value=5.03E-5	After correction for multiple testing, nine miRNAs showed a ...... After correction for multiple testing, nine miRNAs showed a significant association with BD. More...	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
TMEM258	transmembrane protein 258	11q12.2	Mapped by Literature SNP
MYRF	myelin regulatory factor	11q12-q13.1	Mapped by Literature SNP

SNPs in LD with rs174535 (count: 24) View in gBrowse (chr11:61776027..61855668 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 24)

rs_ID	Functional Annotation	r²[population]
rs174578	intron_variant; upstream_gene_variant	1.0[CEU]
rs174547	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1.0[CEU]; 0.913[TSI]
rs174583	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]
rs174576	intron_variant; upstream_gene_variant	1.0[CEU]; 0.832[TSI]
rs4246215	3_prime_UTR_variant; downstream_gene_variant; intron_variant; upstream_gene_variant	0.884[CEU]; 0.884[TSI]
rs174538	5_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant; upstream_gene_variant	0.88[CEU]; 0.805[TSI]
rs174556	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant	0.808[CEU]
rs174548	5_prime_UTR_variant; intron_variant; non_coding_transcript_variant	0.808[CEU]
rs174536	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1.0[CEU]
rs174541	downstream_gene_variant; intron_variant	0.882[CEU]
rs174574	intron_variant; upstream_gene_variant	0.92[CEU]; 0.807[TSI]
rs1535	downstream_gene_variant; intron_variant; upstream_gene_variant	1.0[CEU]; 0.885[TSI]
rs174537	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1.0[CEU]; 0.942[TSI]
rs102275	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.802[TSI]
rs174528	intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.884[CEU]
rs174555	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.808[CEU]
rs174577	intron_variant; upstream_gene_variant	1.0[CEU]; 0.832[TSI]
rs174545	3_prime_UTR_variant; downstream_gene_variant; intron_variant	1.0[CEU]
rs174566	intron_variant; upstream_gene_variant	1.0[CEU]; 0.829[TSI]
rs174550	5_prime_UTR_variant; intron_variant; non_coding_transcript_variant	1.0[CEU]
rs174549	5_prime_UTR_variant; intron_variant; non_coding_transcript_variant	0.808[CEU]
rs174601	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	0.879[CEU]
rs174568	3_prime_UTR_variant; intron_variant; synonymous_variant; upstream_gene_variant	1.0[CEU]; 0.914[TSI]
rs174546	3_prime_UTR_variant; downstream_gene_variant; intron_variant	1.0[CEU]; 0.914[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)