BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Zhang, C., 2015 PMID: 25935703
Citation	Zhang, C., et al. (2015). "ZNF804A Genetic Variation Confers Risk to Bipolar Disorder." Mol Neurobiol.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	candidate-gene association study
Sample Size	For the genetic study, a total of 746 BD patients, including 304 BD-I and 442 BD-II ones, and 762 controls were recruited.
SNP/Region/Marker Size	2 SNPs
Predominant Ethnicity	Mongloid
Population	Han Chinese
Age Group	adults : 16-65 years old

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	All BD patients were recruited from those who were admitted to the Division of Mood Disorders at Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine between November 2006 and August 2014.Individuals with any other psychiatric disorder or chronic physical disease were excluded from this study.
Technique	genotyping
Statistical Method	Demographic data were analyzed using chi-squared, t test, or ANOVA as appropriate. For the meta-analysis, data were summarized using 2Ã—2 tables. The Cochran chi-square-based Q statistical test was performed in order to assess heterogeneity and ensure that each group of studies was suitable for meta-analysis. ORs were pooled using the methods described by DerSimonian, and 95 % CIs were constructed using Woolfâ€™s method. If the result of the heterogeneity test was P>0.05, ORs were pooled according to the fixed-effects model (Mantel-Haenszel methods); otherwise, the random-effects model was used. Funnel plots of the studiesâ€™ effect estimates against sample size were used to assess the validate of meta-analysis
Result Summary	Our results showed that ZNF804A mRNA level in peripheral blood mononuclear cells was significantly higher in BD patients than that in controls (P = 0.01). The rs1344706 showed significant allelic association with BD (P = 0.034). The frequency of T allele of rs1344706 was higher in patients than that in controls (odds ratio = 1.19, 95 % confidence interval 1.03-1.37). After pooling all data, meta-analysis indicated a significant association of rs1344706 with BD (P = 0.0003). Furthermore, we performed an eQTL analysis and observed significant associations between rs1344706 and ZNF804A expression level in hippocampus (P = 0.032) and occipital cortex (P = 0.036). After stratified by diagnosis, the association of rs1344706 with BD was only survived in BD-I (genotypic P = 0.04, allelic P = 0.014), but not in BD-II. Our findings provided supportive evidence for the involvement of ZNF804A rs1344706 in BD, especially in BD-I.

SNPs reported by this study for BD (count: 2)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs359895	ZNF804A	A/T		allelic P-value=0.18, OR (95 % CI)=1.16 (0.98-1.37); genotypic P-value=0.44	No significant differences were observed. No significant differences were observed.	Negative
rs1344706	ZNF804A	T/G		allelic P-value=0.034, OR (95 % CI)=1.19 (1.03-1.37); genotypic P-value=0.08; meta-analysis, P-value=0.24, X²=4.24, df=3, I²=29%, test for overall effect: Z=3.64, P-value=0.0003; allelic P-value=0.014, OR (95 % CI)=1.30 (1.07-1.56), genotypic P-value=0.04 between BD-I and control groups; allelic P-value=0.34, OR (95 % CI)=1.12 (0.95-1.33), genotypic P-value=0.52 between BD-II and control groups	The rs1344706 showed significant allelic association with BD...... The rs1344706 showed significant allelic association with BD. The frequency of T allele of rs1344706 was higher in patients than that in controls. After pooling all data, meta-analysis indicated a significant association of rs1344706 with BD. After stratified by diagnosis, the association of rs1344706 with BD was only survived in BD-I, but not in BD-II. More...	Positive

Genes reported by this study for BD (count: 1)