Study Report
Basic Info
| Reference |
Hou, S. J., 2004 PMID: 15331160
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| Citation |
Hou, S. J., F. C. Yen, et al. (2004). "X-box binding protein 1 (XBP1) C--116G polymorphisms in bipolar disorders and age of onset." Neurosci Lett 367(2): 232-234.
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| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
153 bipolar disorder patients and 174 controls |
| SNP/Region/Marker Size |
1 SNP |
| Predominant Ethnicity |
Mongloid |
| Population |
Chinese |
| Gender |
patients with bipolar disorder (68 men and 85 women); healthy controls (66 men and 108 women) |
| Age Group |
adults
:
BD patients: mean age=38.1 (SD=12.9) years; healthy controls mean age=40.9 (SD=13.1) years
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Detail Info
| Sample Diagnosis |
DSM-IV |
| Technique |
PCR and genotyping |
| Statistical Method |
Genotype and allele frequencies were compared using the chi-square test, with the Fisher's exact test used where necessary. Between-group differences in continuous variables were evaluated using the Student's t-test or one-way analysis of variance. The criterion for significance was set at P < 0.05 for all of the tests. |
| Result Summary |
We were unable, however, to demonstrate a significant association between the C--116G polymorphism and bipolar disorders (P = 0.674 for genotype and P = 0.436 for allele frequency) or age at onset (P = 0.563). Further, no association was demonstrated between this polymorphism and family history in bipolar disorder patients. These negative findings suggest that the XBP1 C--116G polymorphism does not play a major role in the pathogenesis of bipolar disorders in Chinese populations. |
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| XBP1 -116C>G |
XBP1 |
point mutation |
C/G |
|
Genotypic P-value = 0.674, allelic P-value = 0.436 for bipolar disorder; genotypic P-value = 0.176 for bipolar disorder with family history; genotypic P-value = 0.938 for bipolar disorder without family history
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No association was demonstrated between this polymorphism an......
No association was demonstrated between this polymorphism and family history in bipolar disorder patients.
More...
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Negative
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Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| XBP1 |
No association was demonstrated between this polymorphism and family history in bipolar disorder pat......
No association was demonstrated between this polymorphism and family history in bipolar disorder patients. These negative findings suggest that the XBP1 C--116G polymorphism does not play a major role in the pathogenesis of bipolar disorders in Chinese populations.
More...
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Negative
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