BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Oliveira, J., 2013 PMID: 24176535
Citation	Oliveira, J., M. Busson, et al. (2014). "Polymorphism of Toll-like receptor 4 gene in bipolar disorder." J Affect Disord 152-154: 395-402.Oliveira, J., M. Busson, et al. (2014). "Polymorphism of Toll-like receptor 4 gene in bipolar disorder." J Affect Disord 152-154: 395-402.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	572 BD patients and 202 healthy controls
SNP/Region/Marker Size	6 SNPs
Predominant Ethnicity	Caucasian
Population	French
Gender	42%(216) male and 58%(297) female patients, 62%(101) male and 38%(61) female controls
Age Group	adults : BD: 42 y (range:16-67), controls: 43y (range:19-64)

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	Five hundred and seventy-two BD patients meeting DSM-IV criteria for BD type I or II or not otherwise specified, consecutively admitted into three French university-affiliated psychiatry departments. All patients were euthymic at inclusion.
Technique	genotyping by a TaqMan 5'-nuclease assay (Applied Biosystems, Foster city, CA, USA) with allele-specific fluorogenic oligonucleotide probes.
Statistical Method	Comparisons of genotype and allele frequencies between patients and controls were performed using the Chi-square testing. The p values (two tailed) were corrected (pc) using the Bonferroni method and findings were considered statistically significant for pc less than .05. Deviation from the Hardy-Weinberg equilibrium was analyzed using the Chi-square test testing.
Result Summary	We found that rs1927914 AA and rs11536891 TT genotype are more frequent in BD patients than in controls (corrected p; pc=.02 and .02 respectively) particularly in early-onset BD patients (pc=.004 and .006) born during the summer season (pc=.02 and .002 respectively). We also found that rs4986790 AG and rs4986791 CT genotypes were significantly associated with presence of autoimmune thyroiditis (pc=.002). LIMITATIONS: Our results are to be confirmed by replication in independent BD cohorts. We report for the first time a genetic association between BD and TLR-4 a major player of innate immunity. Possible mechanisms underlying bipolar disorders linking altered TLR-4 expression and increased susceptibility to infections and/or autoimmunity are discussed.

SNPs reported by this study for BD (count: 2)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs11536891	TLR4	T/C		rs11536891 TT vs. CT+CC: 71% vs. 61%, P-value=0.008, pc=0.02; OR=1.57, CI95%=1.11-2.22	The analysis of TLR-4 genotype distribution revealed that th...... The analysis of TLR-4 genotype distribution revealed that the TLR-4 rs11536891 T alleles was significantly more prevalent in BD patients than in HC. More...	Positive
rs1927914	TLR4	A/G		rs1927914 AA vs. AG + GG: 48% vs. 37%, P-value=0.008, pc=0.02; OR=1.56, CI95%=1.11-2.20	The analysis of TLR-4 genotype distribution revealed that th...... The analysis of TLR-4 genotype distribution revealed that the homozygous state for TLR-4 rs1927914 A was significantly more prevalent in BD patients than in HC. More...	Positive

Genes reported by this study for BD (count: 1)