Study Report
Basic Info
| Reference |
Wang, Y., 2008 PMID: 18812204
|
| Citation |
Wang, Y., J. Zhang, et al. (2008). "SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population." Prog Neuropsychopharmacol Biol Psychiatry 32(8): 1902-1904.
|
| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
506 bipolar patients and 507 controls |
| SNP/Region/Marker Size |
3 SNPs |
| Predominant Ethnicity |
Mongloid |
| Population |
Han Chinese |
| Gender |
BD patients (222 females and 284 males); healthy controls (220 females and 287 males) |
| Age Group |
BD patients: mean age=37.8 (SD=11.4) years; healthy controls: mean age=36.4 (SD=8.7) years,
|
Detail Info
| Sample Diagnosis |
DSM-IV |
| Sample Status |
Of 506 unrelated bipolar patients, 31 patients attempted suicide. According to DSM-IV criteria, 419 (82.8%) of the cases were diagnosed as being type I Bipolar. |
| Technique |
PCR and genotyping |
| Statistical Method |
For the case-control study, Hardy-Weinberg equilibrium, allelic and genotypic association were calculated on http://202.120.31.177/myanalysis.php. Linkage disequilibrium, allelic and haplotype distribution were estimated using Haploview 4.0RC1. 100,000 permutations were carried out on this software to correct the p values of the alleles. |
| Result Summary |
We found that two individual SNPs showed statistically significant differences between cases and controls in both allele and genotype distribution, but only rs303810 was still significant in allele distribution (p=0.0164) after correction. No obvious linkage disequilibrium or haplotypes were observed among these SNPs. Our results indicate that SCN8A may be a potential susceptibility gene for bipolar disorder in the Han Chinese population. |
SNPs reported by this study for BD (count: 3)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs1601012 |
SCN8A
|
C/A |
|
Allelic P-value = 0.0178, permutated P-value = 0.0523; genotypic P-value = 0.0227
|
This SNP showed statistically significant differences betwee......
This SNP showed statistically significant differences between bipolar patients and controls in both allele and genotype distribution.
More...
|
Positive
|
| rs60637 |
SCN8A
|
C/A |
|
Allelic P-value = 0.3244, permutated P-value = 0.7408; genotypic P-value = 0.5383
|
|
Negative
|
| rs303810 |
SCN8A
|
C/T |
|
Allelic P-value = 0.0047, permutated P-value = 0.0164; genotypic P-value = 0.0051
|
This SNP showed statistically significant differences betwee......
This SNP showed statistically significant differences between bipolar patients and controls in both allele and genotype distribution. only rs303810 was still significant in allele distribution when permutated 100, 000 times on Haploview 4.0RC1.
More...
|
Positive
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| SCN8A |
Two SNPs showed statistically significant differences between bipolar patients and controls in both ......
Two SNPs showed statistically significant differences between bipolar patients and controls in both allele and genotype distribution. Our results indicate that SCN8A may be a potential susceptibility gene for bipolar disorder in the Han Chinese population.
More...
|
Positive
|
