Study Report
Basic Info
| Reference |
Feng, T.,2010 PMID: 20549515
|
| Citation |
Feng, T. and X. Zhu (2010). "Genome-wide searching of rare genetic variants in WTCCC data." Hum Genet 128(3): 269-280.
|
| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
1868 BD individuals, and a shared 2938 controls |
| SNP/Region/Marker Size |
403,456 SNPs |
| Predominant Ethnicity |
|
| Population |
WTCCC collection |
Detail Info
| Statistical Method |
We applied two-stage analysis to the WTCCC data using the method in Zhu et al.(2010) to the ith gene or block (Gi), where i = 1 to N, and N is the total number of genes and blocks.In stage 1, coclassification of risk haplotype, we randomly selected 400 cases and 1,000 controls.In the stage 2 association test, we compared the frequency of risk haplotype set SRi and protective haplotype set SPi, identified in stage 1, between the remaining cases and controls. |
| Result Summary |
We did not observe any genes reaching genome-wide significance.Seven genes showed moderate association evidence. |
SNPs reported by this study for BD (count: 6)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs633702 |
ZNF736
ZNF680
|
|
|
Fisher's exact tests: Empirical P-value(1, 000, 000 permutations)=0.000131
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
| rs6730107 |
ANKMY1
RNPEPL1
|
|
|
Fisher's exact tests: Empirical P-value(1, 000, 000 permutations)=0.000026
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
| rs11025015 |
ZDHHC13
|
|
|
Fisher's exact tests: Empirical P-value(1, 000, 000 permutations)=0.000042
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
| rs11622475 |
TDRD9
|
|
|
Fisher's exact tests: Empirical P-value(1, 000, 000 permutations)=0.000027
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
| rs6861078 |
FBXO38
|
|
|
Fisher's exact tests: Empirical P-value(1, 000, 000 permutations)=0.000071
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
| rs10149544 |
KLHDC1
|
|
|
Fisher's exact tests: Empirical P-value(1, 000, 000 permutations)=0.000148
|
Suggestive association was found.
Suggestive association was found.
|
Trend
|
Genes reported by this study for BD (count: 6)
| Gene |
Statistical Values/Author Comments |
Result Category |
| FBXO38 |
This gene showed moderate association evidence.
This gene showed moderate association evidence.
|
Trend
|
| ZNF680 |
This gene showed moderate association evidence.
This gene showed moderate association evidence.
|
Trend
|
| KLHDC1 |
This gene showed moderate association evidence.
This gene showed moderate association evidence.
|
Trend
|
| RNPEPL1 |
This gene showed moderate association evidence.
This gene showed moderate association evidence.
|
Trend
|
| TDRD9 |
This gene showed moderate association evidence.
This gene showed moderate association evidence.
|
Trend
|
| ZDHHC13 |
This gene showed moderate association evidence.
This gene showed moderate association evidence.
|
Trend
|
