BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	McInnis, M. G.,2003(a) PMID: 14643094
Citation	McInnis, M. G., D. M. Dick, et al. (2003). "Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees." Biol Psychiatry 54(11): 1265-1273.
Disease Type	Bipolar Disorder
Study Design	pedigree
Study Type	Genome-wide linkage study
Sample Size	153 pedigrees
SNP/Region/Marker Size	513 simple sequence repeat markers for whole genome wide
Predominant Ethnicity
Population	NIMH collections

Detail Info

Regions reported by this study for BD (count: 11)

Region	Statistical Values	Author Comments	Result Category
9q21	Linkage analysis: model I, Unconditional NPL = 1.4	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
5q11	Linkage analysis: model II, Unconditional NPL = 0	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
4q35	Linkage analysis: model III, Unconditional NPL = 1	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
7q21	Linkage analysis: model II, Unconditional NPL = 0.7	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
6q24	Linkage analysis: model E, Conditional NPL = 2.7, P-value = 0.003	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
13q21	Linkage analysis: model III, Unconditional NPL = 0.6	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
16p13	Linkage analysis: model E, Conditional NPL = 3.1, P-value = 0.002	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
19q13	Linkage analysis: model III, Unconditional NPL = 0	No significant linkage was found in this region. No significant linkage was found in this region.	Negative
20p12	Linkage analysis: model E, Conditional NPL = 2.6, P-value = 0.008	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
10p12	Linkage analysis: model H, Conditional NPL = 2.8, P-value = 0.001	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
11p15	Linkage analysis: model H, Conditional NPL = 2.7, P-value = 0.002	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend