MTHFR A1298C |
MTHFR |
point mutation |
A/C |
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Fisher exact test, P-value = 0.0004, OR (95% CI)=3.768 (1.753-8.103), chi-square P-value = 0.0003 for CC vs AC & AA genotypes in total patients with BDI; Fisher exact test, P-value = 0.0076, OR (95% CI)=0.609 (0.424-0.875), chi-square P-value = 0.0071 for CC & AC vs AA in total patients with BDI; Fisher exact test, P-value = 0.0009, OR (95% CI)=7.293 (2.018-26.355), chi-square P-value = 0.0005 for CC vs AC & AA genotypes in females patients with BDI; Fisher exact test, P-value = 0.0158, OR (95% CI)=0.516 (0.304-0.876), chi-square P-value = 0.0139 for CC & AC vs AA in females patients with BDI; Fisher exact test, P-value = 0.1246, OR (95% CI)=2.286 (0.841-6.209), chi-square P-value = 0.0971 for CC vs AC & AA genotypes in males patients with BDI; Fisher exact test, P-value = 0.2055, OR (95% CI)=0.705 (0.429-1.158), chi-square P-value = 0.1665 for CC & AC vs AA in males patients with BDI; chi-square P-value = 0.7257, OR (95% CI)=0.916 (0.561-1.496) for CC/AC vs CC/AA; P-value = 0.1448, OR (95% CI)=2.278 (0.734-7.065) for CC/CC vs CC/AA; P-value = 0.5796, OR (95% CI)=0.852 (0.483-1.503) for CT/AA vs CC/AA; P-value = 0.0001, OR (95% CI)=3.417 (1.824-6.401) for CT/AC vs CC/AA; P-value = 0.0002, OR (95% CI)=6.833 (2.160-21.623) for CT/CC vs CC/AA; P-value = 0.0116, OR (95% CI)=3.347 (1.256-8.921) for TT/AA vs CC/AA; P-value = 0.1825, OR (95% CI)=2.44 (0.633-9.408) for TT/AC vs CC/AA; P-value = 0.0505, OR (95% CI)= for TT/CC vs CC/AA in BDI patients
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The frequency of the 1298C allele was 31% and 21% in the tot......
The frequency of the 1298C allele was 31% and 21% in the total group of BD patients and controls, respectively. The frequency of homozygous 1298CC genotype was 3.7-fold times higher in the whole group of bipolar patients as compared to the controls, and was 11% and 3% in those groups, respectively.
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Positive
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