BDgene

Study Report

Basic Info
Reference
Citation Kempisty, B., A. Bober, et al. (2007). "Distribution of 1298A>C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia." Eur Psychiatry 22(1): 39-43.
Disease Type Bipolar I Disorder & Schizophrenia
Study Design case-control
Study Type Candidate-gene association study
Sample Size 200 patients with bipolar affective disorder type I, 200 patients with schizophrenia and 300 control subjects
SNP/Region/Marker Size 1 SNP
Predominant Ethnicity Caucasian
Population Polack
Gender BD patients: 95 females and 105 males, SZpatients: 99 females and 101 males, control: 141 females and 159 males
Age Group adults : BD cases: mean age=40.5 (SD=11) years for females, mean age=36.5 (SD=12) years for males; SZ cases: mean age=46 (SD=14.5) years for females, mean age=43.5 (SD=13) years for males; control: mean age=42 (SD=11) years for females, mean age=39 (SD=9) years for males

Detail Info

Genetic factors reported by this study for BD
Other variants reported by this study for BD (count: 1)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
Other variants reported by this study for SZ/MDD
Disease Variant Name Related Gene Type Statistical Values Description Result Category
SZ MTHFR A1298C MTHFR point mutation Fisher exact test, P-value = 0.0151, OR (95% CI)=2.694(1.207-6.0130), chi-square P-value = 0.0123 for CC vs AC & AA genotypes in total patients with SZ; Fisher exact test, P-value = 0.1158, OR (95% CI)=0.745(0.518-1.070), chi-square P-value = 0.1107 for CC & AC vs AA in total patients with SZ; Fisher exact test, P-value = 0.1671, OR (95% CI)=2.968(0.724-12.163), chi-square P-value = 0.1144 for CC vs AC & AA genotypes in females patients with SZ; Fisher exact test, P-value = 0.1802, OR (95% CI)=0.687(0.406-1.162), chi-square P-value = 0.1604 for CC & AC vs AA in females patients with SZ; Fisher exact test, P-value = 0.0764, OR (95% CI)=2.654(0.993-7.091), chi-square P-value = 0.0446 for CC vs AC & AA genotypes in males patients with SZ; Fisher exact test, P-value = 0.3724, OR (95% CI)=0.794(0.481-1.314), chi-square P-value = 0.3695 for CC & AC vs AA in males patients with SZ; chi-square P-value = 0.9617, OR (95% CI)=0.988 (0.610-1.602) for CC/AC vs CC/AA; P-value = 0.0423, OR (95% CI)=2.929 (0.998-8.595) for CC/CC vs CC/AA; P-value = 0.7257, OR (95% CI)=1.1 (0.645-1.879) for CT/AA vs CC/AA; P-value = 0.0002, OR (95% CI)=3.221 (1.711-6.067) for CT/AC vs CC/AA; P-value = 0.3475, OR (95% CI)=1.952 (0.473-8.067) for CT/CC vs CC/AA; P-value = 0.0017, OR (95% CI)=4.184 (1.623-10.787) for TT/AA vs CC/AA; P-value = 0.1545, OR (95% CI)=0 for TT/AC vs CC/AA; P-value = 0.0062, OR (95% CI)= for TT/CC vs CC/AA in SZ patients The results confirm association of SZ with the 1p36.3 MTHFR locus. The frequency of heterozygous 1298CA genotype was higher in patients as compared to controls but was not significantly different. Gender classification of patients did not indicate association of homozygous 1298CC genotype with either schizophrenia in the female nor male patients. Positive

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ MTHFR The results confirm association of schizophrenia with the 1p36.3 MTHFR locus and with the methyl group transfer using folatedependent one-carbon pathway. Positive