SNP Report

Basic Info

Name	rs2075680 dbSNP Ensembl
Location	chr5:37840540 - 37840540(1)
Variant Alleles	C/A
Ancestral Allele	C
Minor Allele	A
Minor Allele Frequence	0.22484
Functional Annotation	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000637595, ENST00000637926); non_coding_transcript_exon_variant(ENST00000503382); non_coding_transcript_variant(ENST00000503382, ENST00000637595, ENST00000637926); upstream_gene_variant(ENST00000326524, ENST00000381826, ENST00000427982, ENST00000515058)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Safari, R., 2014	C/A		P-value=0.04, OR=2.11,CI=1.0042-4.4434 P-value=0.04, OR=2.11,CI=1.0042-4.4434	Performing Chi-square test and considering P-value threshold...... Performing Chi-square test and considering P-value threshold at 0.05 there were significant differences in the allele frequency for rs2075680 C>A SNP between BD patients and healthy volunteers(p=0.04; OR=2.11,95%CI=[1.0042â€“4.4434]) also between male patients and male volunteers(p=0.03; OR=3.55, 95%CI=[1.0367â€“12.17]). However, after multiple test corrections with the P-value of 0.005 the significance disappeared. More...	Positive

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
GDNF	glial cell derived neurotrophic factor	5p13.1-p12	1(1/0/0)
GDNF-AS1	GDNF antisense RNA 1 (head to head)	5p13.2	Mapped by Literature SNP

SNPs in LD with rs2075680 (count: 0) View in gBrowse (chr5:37840540..37840540 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)