BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Ates, O.,2013 PMID: 23384717
Citation	Ates, O., et al. (2013). "Association Between 1603C>T Polymorphism of DBH Gene and Bipolar Disorder in a Turkish Population." Gene.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	106 patients with bipolar disorder and 106 healthy subjects
SNP/Region/Marker Size	3 SNPs
Predominant Ethnicity
Population	Turkish
Gender	106 patients with bipolar disorder (53 males and 52 females), and 106 healthy subjects (54 males and 52 females)
Age Group	adults : 106 patients with bipolar disorder (the mean age: 41.13, SD = 12.234 years), and 106 healthy subjects (the mean age: 38.20, SD = 11.525 years)

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	The study group consisted of 106 patients with bipolar disorder (53 males and 52 females; the mean age: 41.13, SD = 12.234 years), and 106 healthy subjects (54 males and 52 females; the mean age: 38.20, SD = 11.525 years) as the control group. All participants were living in Tokat city of central Anatolia region of Turkey. All bipolar patients were followed up at the Outpatient Clinic of the Psychiatry Department of Gaziosmanpasa University, School of Medicine. They were all diagnosed as bipolar disorder according to the DSM-IV (Diagnostic and Statistical Manual-IV) criteria (American Psychiatric Association 1994). The control subjects were matched for age, gender and the geographic area with the bipolar patients.
Technique	Genotyping
Statistical Method	The statistical analysis was performed by using PEPI 3.0 (available at:http://www.usdinc.com/pepi.html). The distribution of DBH gene polymorphisms between the bipolar disorder patients and the healthy controls were compared by using the chi square test or Fisher's exact test.
Result Summary	The results showed statistically significant associations for genotypic and allelic distribution between the 1603C>T polymorphism and bipolar disease (p=0,0012 and p=0,034, respectively). There was no association observed between the genotype and allelic frequencies for -1021C>T and 444G>A polymorphisms and bipolar disorder. CONCLUSIONS: Our data suggests that the 1603C>T polymorphism of the DBH gene is associated with susceptibility to bipolar disorder in Turkish population.

SNPs reported by this study for BD (count: 3)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs1108580	DBH	C/T		Genotypic P-value = 0.9879;allelic P-value = 0.500	There was no association observed between the genotype and a...... There was no association observed between the genotype and allelic frequencies for -1021C>T polymorphism and bipolar disorder. More...	Negative
rs1611115	DBH	C/T		Genotypic P-value = 0.0012;allelic P-value = 0.034,OR(95%CI) = 2.22 (0.88-6.08)	The results showed statistically significant associations fo...... The results showed statistically significant associations for genotypic and allelic distribution between the 1603C>T polymorphism and bipolar disease. More...	Positive
rs6271	DBH DBH-AS1	G/A		Genotypic P-value = 0.8850;allelic P-value = 0.348	There was no association observed between the genotype and a...... There was no association observed between the genotype and allelic frequencies for 444G>A polymorphism and bipolar disorder. More...	Negative

Genes reported by this study for BD (count: 1)