BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Kakiuchi, C., 2007 (b) PMID: 17346882
Citation	Kakiuchi, C., M. Ishiwata, et al. (2007). "Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder." Neurosci Lett 417(3): 316-321.
Disease Type	Bipolar Disorder
Study Design	case-control and family-based
Study Type	Candidate-gene association study
Sample Size	438 BD patients, 532 controls and 237 trios
SNP/Region/Marker Size	9 SNPs
Predominant Ethnicity	Caucasian and Mongloid
Population	Japanese, NIMH collection
Gender	BD patients in Japanese population: 210 males and 228 females; control: 261 males and 271 females
Age Group	adults : BD cases in Japanese population: mean age=50.2 (SD=13.5) years; control: mean age=43.9 (SD=15.0) years

Detail Info

SNPs reported by this study for BD (count: 9)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs4821907	RPS19BP1 ATF4	C/G		Fisher's exact test, genotypic P-value = 0.929, allelic P-value = 0.805 in MDMD samples, Fisher's exact test, genotypic P-value = 0.696, allelic P-value = 0.603 in MPS samples, Fisher's exact test, genotypic P-value = 0.62, allelic P-value = 0.518 in total samples; TDT P-value = 0.577, X²=0.311 in NIMH trios	There were no significant differences in both genotype and a...... There were no significant differences in both genotype and allele frequencies in both of total samples and independently collected age-matched samples. TDT analysis also showed no association of the SNP to the illness. More...	Negative
rs283525	IL4I1 ATF5 NUP62	C/T		Fisher's exact test, genotypic P-value = 0.876, allelic P-value = 0.61 in MDMD samples, Fisher's exact test, genotypic P-value = 0.681, allelic P-value = 0.901 in MPS samples, Fisher's exact test, genotypic P-value = 0.778, allelic P-value = 0.893 in total samples; TDT P-value = 0.554, X²=0.351 in NIMH trios	There were no significant differences in both genotype and a...... There were no significant differences in both genotype and allele frequencies in both of total samples and independently collected age-matched samples. TDT analysis also showed no association of the SNP to the illness. More...	Negative
rs283524	IL4I1 ATF5 NUP62	C/G		Fisher's exact test, genotypic P-value = 1, allelic P-value = 0.947 in MDMD samples, Fisher's exact test, genotypic P-value = 0.2, allelic P-value = 0.196 in MPS samples, Fisher's exact test, genotypic P-value = 0.43, allelic P-value = 0.399 in total samples; TDT P-value = 0.881, X²=0.022 in NIMH trios	There were no significant differences in both genotype and a...... There were no significant differences in both genotype and allele frequencies in both of total samples and independently collected age-matched samples. TDT analysis also showed no association of the SNP to the illness. More...	Negative
rs1152230	IL4I1 ATF5 NUP62	A/G		Fisher's exact test, genotypic P-value = 0.367, allelic P-value = 0.514 in MDMD samples, Fisher's exact test, genotypic P-value = 0.729, allelic P-value = 0.485 in MPS samples, Fisher's exact test, genotypic P-value = 0.763, allelic P-value = 0.997 in total samples; TDT P-value = 0.783, X²=0.076 in NIMH trios	There were no significant differences in both genotype and a...... There were no significant differences in both genotype and allele frequencies in both of total samples and independently collected age-matched samples. TDT analysis also showed no association of the SNP to the illness. More...	Negative
rs882565	ATF4 RPS19BP1	C/T		Fisher's exact test, genotypic P-value = 0.869, allelic P-value = 0.621 in MDMD samples, Fisher's exact test, genotypic P-value = 0.634, allelic P-value = 0.989 in MPS samples, Fisher's exact test, genotypic P-value = 0.638, allelic P-value = 0.664 in total samples; TDT P-value = 0.486, X²=0.486 in NIMH trios	There were no significant differences in both genotype and a...... There were no significant differences in both genotype and allele frequencies in both of total samples and independently collected age-matched samples. TDT analysis also showed no association of the SNP to the illness. More...	Negative
rs8667	IL4I1 ATF5 NUP62	A/G		Fisher's exact test, genotypic P-value = 0.123, allelic P-value = 0.205 in MDMD samples, Fisher's exact test, genotypic P-value = 0.905, allelic P-value = 0.77 in MPS samples, Fisher's exact test, genotypic P-value = 0.199, allelic P-value = 0.23 in total samples; TDT P-value = 0.889, X²=0.02 in NIMH trios	There were no significant differences in both genotype and a...... There were no significant differences in both genotype and allele frequencies in both of total samples and independently collected age-matched samples. TDT analysis also showed no association of the SNP to the illness. More...	Negative
rs8647	IL4I1 ATF5 NUP62	A/G		Fisher's exact test, genotypic P-value = 0.261, allelic P-value = 0.35 in MDMD samples, Fisher's exact test, genotypic P-value = 0.705, allelic P-value = 0.92 in MPS samples, Fisher's exact test, genotypic P-value = 0.253, allelic P-value = 0.517 in total samples; TDT P-value = 0.889, X²=0.02 in NIMH trios	There were no significant differences in both genotype and a...... There were no significant differences in both genotype and allele frequencies in both of total samples and independently collected age-matched samples. TDT analysis also showed no association of the SNP to the illness. More...	Negative
rs6519194	ATF4	A/G		Fisher's exact test, genotypic P-value = 0.6, allelic P-value = 0.429 in MDMD samples, Fisher's exact test, genotypic P-value = 0.78, allelic P-value = 0.757 in MPS samples, Fisher's exact test, genotypic P-value = 0.7, allelic P-value = 0.681 in total samples; TDT P-value = 0.556, X²=0.346 in NIMH trios	There were no significant differences in both genotype and a...... There were no significant differences in both genotype and allele frequencies in both of total samples and independently collected age-matched samples. TDT analysis also showed no association of the SNP to the illness. More...	Negative
rs1028321	RPS19BP1 ATF4	A/G		Fisher's exact test, genotypic P-value = 0.236, allelic P-value = 0.089 in MDMD samples, Fisher's exact test, genotypic P-value = 0.997, allelic P-value = 0.942 in MPS samples, Fisher's exact test, genotypic P-value = 0.436, allelic P-value = 0.204 in total samples; TDT P-value = 0.576, X²=0.312 in NIMH trios	There were no significant differences in both genotype and a...... There were no significant differences in both genotype and allele frequencies in both of total samples and independently collected age-matched samples. TDT analysis also showed no association of the SNP to the illness. More...	Negative

Haplotypes reported by this study for BD (count: 16)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs1152230 - rs283524 - rs283525		ATF5	COCAPHASE global P-value = 0.4677 in Japanese samples; TDT P-value = 0.1915 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs1152230 - rs283524		ATF5	COCAPHASE global P-value = 0.3182 in Japanese samples; TDT P-value = 0.8767 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs882565 - rs4821907 - rs1028321		ATF4	COCAPHASE global P-value = 0.287 in Japanese samples; TDT P-value = 0.4214 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs882565 - rs4821907		ATF4	COCAPHASE global P-value = 0.5575 in Japanese samples; TDT P-value = 0.404 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs6519194 - rs882565 - rs4821907 - rs1028321	G-C-C-G	ATF4	COCAPHASE global P-value = 0.4931 in Japanese samples; TDT P-value = 0.5813 in NIMH samples; global P-value = 0.0156 in BPII patients, P-value = 0.00143 for G-C-C-G haplotype	Haplotype analysis of ATF4 in BPII patients and controls of ...... Haplotype analysis of ATF4 in BPII patients and controls of Japanese samples showed the significant association. rs6519194(G)-rs882565(C)-rs4821907(C)-rs1028321(G) haplotype was significantly less in cases. More...	Positive
rs6519194 - rs882565 - rs4821907		ATF4	COCAPHASE global P-value = 0.8182 in Japanese samples; TDT P-value = 0.5464 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs6519194 - rs882565		ATF4	COCAPHASE global P-value = 0.9401 in Japanese samples; TDT P-value = 0.5841 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs4821907 - rs1028321		ATF4	COCAPHASE global P-value = 0.1748 in Japanese samples; TDT P-value = 0.5742 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs283525 - rs8647 - rs8667		ATF5	COCAPHASE global P-value = 0.4183 in Japanese samples; TDT P-value = 0.565 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs8647 - rs8667		ATF5	COCAPHASE global P-value = 0.3635 in Japanese samples; TDT P-value = 0.8887 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs283524 - rs283525 - rs8647 - rs8667		ATF5	COCAPHASE global P-value = 0.4648 in Japanese samples; TDT P-value = 0.06708 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs283525 - rs8647		ATF5	COCAPHASE global P-value = 0.5999 in Japanese samples; TDT P-value = 0.565 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs283524 - rs283525		ATF5	COCAPHASE global P-value = 0.3844 in Japanese samples; TDT P-value = 0.2365 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs283524 - rs283525 - rs8647		ATF5	COCAPHASE global P-value = 0.4337 in Japanese samples; TDT P-value = 0.067 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs1152230 - rs283524 - rs283525 - rs8647		ATF5	COCAPHASE global P-value = 0.4602 in Japanese samples; TDT P-value = 0.08347 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative
rs1152230 - rs283524 - rs283525 - rs8647 - rs8667		ATF5	COCAPHASE global P-value = 0.5119 in Japanese samples; TDT P-value = 0.08347 in NIMH samples	Haplotype analysis did not show significant difference in bo...... Haplotype analysis did not show significant difference in both of the ethnicities. More...	Negative

Genes reported by this study for BD (count: 2)

Gene	Statistical Values/Author Comments	Result Category
ATF5	We did not find the association of ATF5 with bipolar disorder by genetic association study of Japane...... We did not find the association of ATF5 with bipolar disorder by genetic association study of Japanese samples and NIMH trio samples. In addition, there was no difference of mRNA expression levels between BPI patients and controls. More...	Negative
ATF4	There were no significant differences in both genotype and allele frequencies in four SNPs of ATF4 l...... There were no significant differences in both genotype and allele frequencies in four SNPs of ATF4 locus; TDT analysis also showed no association to the illness; nominal association of ATF4 with bipolar II patients was observed, but itwas not significant after correction of multiple testing; Haplotype analysis of ATF4 in BPII patients and controls of Japanese samples showed the significant association More...	Positive