BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Turgut, G.,2009 PMID: 18165917
Citation	Turgut, G., E. Kurt, et al. (2009). Association of MDR1 C3435T polymorphism with bipolar disorder in patients treated with valproic acid. Mol Biol Rep 36(3): 495-499.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	104 BD patients and 169 controls
SNP/Region/Marker Size	1 variant
Predominant Ethnicity
Population	Turkish
Gender	Male/female:39/65 in BD patients and 68/110 in controls
Age Group	Adults : Mean age(SD)(year):39.8(10.4) in BD patients and 37.6(8.6) in controls

Detail Info

Sample Diagnosis	DSM
Sample Status	Totally, 104 patients who aged from 18 to 65 years and met DSM-IV criteria for bipolar disorder were admitted to the study. All patients were recruited from the study centers and were Turkish in origin. There were no patients with clinically significant organic disorder, mental retardation, any psychiatric disorder other than bipolar disorder, and a history of alcohol and drug abuse in the previous 12 months. Pregnant or lactating women and those in the reproductive age without adequate contraception were also excluded. The control group consisted of 169 healthy subjects who aged from 18 to 65 years, without a history of neuropsychiatric disorder. They were also Turkish in origin.
Technique	genotyping
Statistical Method	SPSS 13.0 for windows computing program was used for statistical analyses of the data. Both parametric and nonparametric tests were used for evaluation of the data. The difference in allele and genotype frequencies between the patients and controls was determined using the chi-square test.
Result Summary	There was statistically significant difference between the genotypes of bipolar patients (CT 91.2%, TT 6.8%, and CC 2%) and controls (CT 52.7%, TT 26%, CC 21.3%) although their allelic distribution was similar. The serum valproic acid concentrations of the patients with CT, TT and CC genotypes were 72.92 +/- 20.55, 80.47 +/- 14.01 and 68.29 +/- 12.17 microg/ml, respectively, and there was no significant difference between the C3435T genotypes.

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
MDR1 exon26 C3435T	ABCB1	point mutation	C/T		chi-square test:genotype, X² = 49.5, df = 2, P-value < 0.001;allele, X² = 0.05, df = 1, P-value < 0.810	Significant associations were found in genotype frequencies. Significant associations were found in genotype frequencies.	Positive

Genes reported by this study for BD (count: 1)