BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Region Report

Basic Info

Region Name	14q21
Chromosome Position	chr14:37400000-50400000
No. of Studies (Positive/Negative/Trend)	3(2/0/1)

Region related studies (count: 3)

Reference	Markers	Statistical Values	Author Comments	Result Category
Xu, H.,2011	D14S306, D14S1048	Family-Based Association: For marker D14S306, for BP2, allel...... Family-Based Association: For marker D14S306, for BP2, allele 6, Z-score = 2.05, P-value = 0.040409, Perm.P-value = 0.040958; For marker D14S1048, for BP2, allele 10, Z-score = -2.044, P-value = 0.040951, Perm.P-value = 0.043478; allele 13, Z-score = 2.646, P-value = 0.008151, Perm.P-value = 0.008258; allele 4, Z-score = -2.553, P-value = 0.010674, Perm.P-value = 0.01256; allele 6, Z-score = 2.077, P-value = 0.03782, Perm.P-value = 0.037744; allele 7, Z-score = 2.443, P-value = 0.014556, Perm.P-value = 0.014445; Global P-value = 0.012825, Perm.P-value = 0.025058 More...	Significant associations were found in BP2. Significant associations were found in BP2.	Positive
Liu, J.,2003	D14S306	Multipoint ASP results: LOD = 2.36, Model BP2 Multipoint ASP results: LOD = 2.36, Model BP2	Suggestive linkage was found in this region. Suggestive linkage was found in this region.	Trend
Xu, H.,2010	D14S306, D14S1048	Association analysis: For marker D14S306, for BP2, allele 6...... Association analysis: For marker D14S306, for BP2, allele 6, z-score = 2.05, FBAT P-value = 0.040409, perm P-value = 0.040958; For marker D14S1048, for BP2, allele 10, z-score = -2.044, FBAT P-value = 0.040951, perm P-value = 0.043478; allele 13, z-score = 2.646, FBAT P-value = 0.008151, perm P-value = 0.008258; For marker D14S1068, for BP2, allele 4, z-score = -2.553, FBAT P-value = 0.010674, perm P-value = 0.01256; allele 6, z-score = 2.077, FBAT P-value = 0.03782, perm P-value = 0.037744; allele 7, z-score = 2.443, FBAT P-value = 0.014556, perm P-value = 0.014445; Global FBAT P-value = 0.012825, perm P-value = 0.025058; linkage study: For marker D14S306, for BP2, ASP model, LOD = 0.65 in new pedigrees(N = 16); LOD = 1.9 in all pedigrees(N = 56) More...	Significant associations were found in BP2. Significant associations were found in BP2.	Positive

Region related genes (count: 5)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
POLE2	polymerase (DNA directed), epsilon 2, accessory subunit	14q21-q22	1(1/0/0)
KLHDC1	kelch domain containing 1	14q21.3	2(1/0/1)
LRR1	leucine rich repeat protein 1	14q21.3	1(1/0/0)
GEMIN2	gem (nuclear organelle) associated protein 2	14q21.1	1(0/1/0)
SSTR1	somatostatin receptor 1	14q13	1(1/0/0)

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Region: chr14:37400000..50400000 View in gBrowse