SNP Report

Basic Info

Name	rs12140107 dbSNP Ensembl
Location	chr1:66126190 - 66126190(1)
Variant Alleles	A/G
Ancestral Allele	A
Minor Allele	G
Minor Allele Frequence	0.0760783
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000329654, ENST00000341517, ENST00000423207, ENST00000526666, ENST00000532040); non_coding_transcript_variant(ENST00000526666, ENST00000532040)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Kahler, A. K., 2010	A/G	A	genotype test: P-value = 0.008, allele test: P-value = 0.023...... genotype test: P-value = 0.008, allele test: P-value = 0.023 and OR=1.27(1.03-1.56) for all samples, P-value = 0.042 and OR=1.29(1.00-1.66) in Denmark samples, OR=1.22 in Normay samples. More...	nominally significant in allele- or genotype-based tests, no...... nominally significant in allele- or genotype-based tests, none of the tagSNPs remained significantly associated with BP after correction for multiple testing. None of the tagSNPs nominally associated with BP were associated with positive or negative symptoms in the BP sample. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
PDE4B	phosphodiesterase 4B, cAMP-specific	1p31	3(1/2/0)

SNPs in LD with rs12140107 (count: 2) View in gBrowse (chr1:66120279..66145285 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs17128445		intron_variant; non_coding_transcript_variant	0.847[CEU]
rs17421832		intron_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)