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Study Report
| Comment on Study | View All Comments on Study |
Basic Info
| Reference | Bloch, P. J., 2010 PMID: 20800640 |
|---|---|
| Citation | Bloch, P. J., A. E. Weller, et al. (2010). "Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder." Prog Neuropsychopharmacol Biol Psychiatry 34(8): 1515-9. |
| Disease Type | Bipolar I Disorder |
| Study Design | case-control |
| Study Type | Candidate-gene association study |
| Sample Size | n=556 BPD patients and n=735 controls |
| SNP/Region/Marker Size | 9 SNPs |
| Predominant Ethnicity | Caucasian |
| Population | European |
| Gender | 38% male for patients, 51% male for controls |
| Age Group | adult : mean age: 41.6 years for patients, mean age: 38.5 years for controls. |
Detail Info
| Sample Diagnosis | DSM-IV |
|---|---|
| Technique | Genotyping was performed using the Applied Biosystems Inc. (ABI) 'ssays-on-demand' (ABI, Foster City, CA, USA) SNP genotyping assay as per manufacturers protocol. |
| Statistical Method | Genotypes and allele frequencies were compared between groups using Chi square contingency analysis. A two-tailed type I error rate of 5% was chosen for the analysis. Linkage disequilibrium (LD) and haplotype frequencies were estimated using the Haploview software (version 4.0). Correction for multiple testing was performed using permutation correction by the Haploview program. Power analysis was performed using the Quanto program. |
| Result Summary | Single marker analysis revealed several associations between IMPA2 variations and BPD, which were subsequently rendered non-significant after correction for multiple testing. |
| SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|---|
| rs1787984 | IMPA2 | A/G | G | genotype test P-value = 0.165, allele test P-value = 0.082 | Negative | |
| rs3786285 | IMPA2 | T/C | C | genotype test P-value = 0.708, allele test P-value = 0.944 | Negative | |
| rs3974759 | IMPA2 | T/A | A | genotype test P-value = 0.397, allele test P-value = 0.168 | Negative | |
| rs585247 | IMPA2 | T/C | C | genotype test P-value = 0.0218, allele test P-value = 0.069 | Single marker analysis revealed the associations between var...... Single marker analysis revealed the associations between variants and BPD on genotypic level; however; no associations remained statistically significant after correction for multiple testing. More... | Positive |
| rs589247 | IMPA2 | G/A | A | genotype test P-value = 0.383, allele test P-value = 0.242 | Negative | |
| rs669838 | IMPA2 | G/T | T | genotype test P-value = 0.03, allele test P-value = 0.0487 | Single marker analysis revealed the associations between var...... Single marker analysis revealed the associations between variants and BPD on both genotypic and allelic level; however; no associations remained statistically significant after correction for multiple testing. More... | Positive |
| rs650727 | IMPA2 | C/T | T | genotype test P-value = 0.257, allele test P-value = 0.384 | Negative | |
| rs636173 | IMPA2 | G/A | A | genotype test P-value = 0.0522, allele test P-value = 0.0933 | Negative | |
| rs613993 | IMPA2 | A/G | G | genotype test P-value = 0.737, allele test P-value = 0.699 | Negative |
| Markers | Haplotype | Related Gene(s)/Region(s) | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|
| rs1787984 - rs585247 - rs3974759 | ATT | IMPA2 | Chi square=2.567, P-value = 0.1091, permutation P-value = 0.6965 | Haplotype analysis did not show any statistically significan...... Haplotype analysis did not show any statistically significant associations. More... | Negative |
| rs650727 - rs589247 - rs669838 - rs636173 | CGTA | IMPA2 | Chi square=1.627, P-value = 0.2021, permutation P-value = 0.9014 | Haplotype analysis did not show any statistically significan...... Haplotype analysis did not show any statistically significant associations. More... | Negative |
| rs650727 - rs589247 - rs669838 - rs636173 | CGGG | IMPA2 | Chi square=2.783, P-value = 0.0953, permutation P-value = 0.6677 | Haplotype analysis did not show any statistically significan...... Haplotype analysis did not show any statistically significant associations. More... | Negative |
| rs650727 - rs589247 - rs669838 - rs636173 | TATA | IMPA2 | Chi square=2.071, P-value = 0.1501, permutation P-value = 0.8476 | Haplotype analysis did not show any statistically significan...... Haplotype analysis did not show any statistically significant associations. More... | Negative |
| rs1787984 - rs585247 - rs3974759 | ATA | IMPA2 | Chi square=1.68, P-value = 0.195, permutation P-value = 0.8942 | Haplotype analysis did not show any statistically significan...... Haplotype analysis did not show any statistically significant associations. More... | Negative |
| rs1787984 - rs585247 - rs3974759 | GTT | IMPA2 | Chi square=1.479, P-value = 0.2239, permutation P-value = 0.9358 | Haplotype analysis did not show any statistically significan...... Haplotype analysis did not show any statistically significant associations. More... | Negative |
| rs1787984 - rs585247 - rs3974759 | GCA | IMPA2 | Chi square=3.772, P-value = 0.0521, permutation P-value = 0.3893 | Haplotype analysis did not show any statistically significan...... Haplotype analysis did not show any statistically significant associations. More... | Negative |
| rs1787984 - rs585247 - rs3974759 | HTA | IMPA2 | Chi square=1.61, P-value = 0.2044, permutation P-value = 0.9069 | Haplotype analysis did not show any statistically significan...... Haplotype analysis did not show any statistically significant associations. More... | Negative |
| Gene | Statistical Values/Author Comments | Result Category |
|---|---|---|
| IMPA2 | Our study did not show strong support for an association between the tested IMPA2 polymorphisms and ...... Our study did not show strong support for an association between the tested IMPA2 polymorphisms and susceptibility to BPD. More... | Negative |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: March 31, 2016