Study Report

Reference	Li, T.,2013 PMID: 22404659
Citation	Li, T., et al. (2013). "FoxP2 is significantly associated with schizophrenia and major depression in the Chinese Han Population." World J Biol Psychiatry 14(2): 146-150.
Disease Type	Bipolar Disorder & Schizophrenia & Major depressive disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	1135 schizophrenia patients, 1135 unrelated major depression patients, 1135 unrelated bipolar disorder patients and 1135 unrelated normal controls
SNP/Region/Marker Size	12 SNPs
Predominant Ethnicity	Mongloid
Population	Chinese
Gender	male/female:630/505 in SZ,483/652 in MDD and 618/517 in BD;369/766 in controls
Age Group	adults : Mean age(DS)(year):35.2(7.2) in SZ,35(11.6) in MDD,36.6(13.8) in BD and 58.7(9.9) in controls

Sample Diagnosis	DSM-IV
Sample Status	All subjects were born in Shanghai and were interviewed by two independent psychiatrists and diagnosed strictly according to DSM-IV criteria. Controls were randomly selected from the Shanghai general population. We chose older healthy volunteers as controls, as they are much more likely to pass the risk age of schizophrenia.
Technique	Genotyping
Statistical Method	We calculated Hardy-Weinberg equilibrium, allelic association, genotypic association and odds ratio on the SHEsis software platform (http://analysis.bio-x.cn) (Shi and He 2005). We corrected the P values of genotype and allele by Bonferroni correction in which the P values obtained are multiplied by the number of tests performed in the same dataset; the corrected values are usually considered significant if they are below 0.05.
Result Summary	We found rs10447760 was significantly associated with schizophrenia (allelic P = 0.00069) and major depression (allelic P = 0.0011). Conclusions. Our study indicated that the rare variant rs10447760 in FoxP2 may play an important role in schizophrenia and major depression in the Chinese Han population.