BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Abou Jamra, R.,2005(b) PMID: 15852064
Citation	Abou Jamra, R., I. Sircar, et al. (2005). A family-based and case-control association study of trace amine receptor genes on chromosome 6q23 in bipolar affective disorder. Mol Psychiatry 10(7): 618-620.
Disease Type	Bipolar Disorder
Study Design	case-control and family-based
Study Type	Candidate-gene association study
Sample Size	118 parent-offspring triads with BPAD
SNP/Region/Marker Size	5 SNPs
Predominant Ethnicity

Detail Info

SNPs reported by this study for BD (count: 5)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs8192624	TAAR6	G/A		In family base study: TDT P-value = 0.014; in case-control study: ARMITAGES TREND TEST P-values (odds ratio, 95% CI)=0.024 (1.63, 1.03-2.55).	Significant association was observed in both familiy-base st...... Significant association was observed in both familiy-base study and case-control study. More...	Positive
rs8192620	TAAR1	A/G		In family base study: TDT P-value = 0.380	No significant association was observed. No significant association was observed.	Negative
rs7772821	TAAR6 TAAR8	T/G		In family base study: TDT P-value = 0.710; in case-control study: ARMITAGES TREND TEST P-values (odds ratio, 95% CI)=0.604 (1.06, 0.75-1.52)	No significant association was observed. No significant association was observed.	Negative
rs8192625	TAAR6	G/A		In family base study: TDT P-value = 0.063; in case-control study: ARMITAGES TREND TEST P-values (odds ratio, 95% CI)=0.250 (1.36, 0.87-2.15).	No significant association was observed. No significant association was observed.	Negative
rs8192627	TAAR8	A/C		In family base study: TDT P-value = 0.760	No significant association was observed. No significant association was observed.	Negative

Genes reported by this study for BD (count: 3)

Gene	Statistical Values/Author Comments	Result Category
TAAR8	We observed no significant TDT results in TRAR5. We observed no significant TDT results in TRAR5.	Negative
TAAR6	The combined analysis of both samples with rs8192624 resulted in a significant association (P=0.004)...... The combined analysis of both samples with rs8192624 resulted in a significant association (P=0.004).Our study provides evidence for the involvement of the TRAR4 locus in the etiology of BPAD. More...	Positive
TAAR1	We observed no significant TDT results in TRAR1. We observed no significant TDT results in TRAR1.	Negative