Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	PRKAG2
Symbol Alias	AAKG, AAKG2, H91620p, WPWS, CMH6
Approved Name	protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Name Alias	AMPK gamma2
Location	7q35-q36
Position	chr7:151556111-151877125, -1
External Links	HGNC: 9386 Entrez Gene: 51422 Ensembl: ENSG00000106617 UCSC: uc003wkk.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015	SNP: rs7797944	PRKAG2 has been implicated in BPD [56], MDD [57], ADHD and autism.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 37)

GO terms by PBA (count: 0)

GO terms by database search (count: 37)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0046320	regulation of fatty acid oxidation	biological process	TAS[9208914]	2
GO:0006468	protein phosphorylation	biological process	IEA	42
GO:0008603	cAMP-dependent protein kinase regulator activity	molecular function	IMP[15877279]	2
GO:0006112	energy reserve metabolic process	biological process	TAS	19
GO:0045860	positive regulation of protein kinase activity	biological process	IMP[15877279]	8
GO:0007005	mitochondrion organization	biological process	TAS	8
GO:0005977	glycogen metabolic process	biological process	IMP[11827995]	5
GO:0030295	protein kinase activator activity	molecular function	IMP[15877279]	2
GO:0061024	membrane organization	biological process	TAS	14
GO:0006469	negative regulation of protein kinase activity	biological process	IDA[17255938]	7
GO:0007050	cell cycle arrest	biological process	TAS	10
GO:0019217	regulation of fatty acid metabolic process	biological process	IMP[15877279]	1
GO:0019901	protein kinase binding	molecular function	IDA[10698692]	29
GO:0031588	AMP-activated protein kinase complex	cellular component	IDA[15877279]	2
GO:0035556	intracellular signal transduction	biological process	IMP[15877279]	38
GO:0005524	ATP binding	molecular function	IDA[15877279]	118
GO:0042304	regulation of fatty acid biosynthetic process	biological process	TAS	1
GO:0008286	insulin receptor signaling pathway	biological process	TAS	15
GO:0006633	fatty acid biosynthetic process	biological process	IEA	4
GO:0016208	AMP binding	molecular function	IEA	1
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:0044255	cellular lipid metabolic process	biological process	TAS	13
GO:0046324	regulation of glucose import	biological process	TAS[11827995]	1
GO:0006996	organelle organization	biological process	TAS	23
GO:0006853	carnitine shuttle	biological process	TAS	1
GO:0004679	AMP-activated protein kinase activity	molecular function	IEA	1
GO:0008607	phosphorylase kinase regulator activity	molecular function	IMP[15877279]	1
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	biological process	IMP[15877279]	2
GO:0071901	negative regulation of protein serine/threonine kinase activity	biological process	IDA[17255938]	1
GO:0005829	cytosol	cellular component	TAS	223
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0004862	cAMP-dependent protein kinase inhibitor activity	molecular function	IDA[17255938]	4
GO:0005615	extracellular space	cellular component	IDA[22664934]	85
GO:0043531	ADP binding	molecular function	IDA[15877279]	4
GO:0006754	ATP biosynthetic process	biological process	TAS[11371514]	1
GO:0016126	sterol biosynthetic process	biological process	TAS[9208914]	1
GO:0006110	regulation of glycolytic process	biological process	IMP[15877279]	1

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04920	Adipocytokine signaling pathway	8

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04910	Insulin signaling pathway	10

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
leptinPathway	Reversal of Insulin Resistance by Leptin	2

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PRKAG2	PRKAB1	NO	yeast 2-hybrid	10698692
PRKAG2	PRKAG1	NO	yeast 2-hybrid	10698692
PRKAG2	PRKAB2	NO	yeast 2-hybrid	10698692

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7797944	chr7:151691164 - 151691164(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(1/0/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 7	chr7:0-159345973	3 (0/3/0)
7q34-qter	chr7:138500000-159345973	1 (0/1/0)
7q36	chr7:148200000-159345973	3 (0/0/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:151556111..151877125 View in gBrowse