Study Report
Basic Info
| Reference |
Puertollano, R.,1995 PMID: 8546157
|
| Citation |
Puertollano, R., G. Visedo, et al. (1995). "Lack of association between manic-depressive illness and a highly polymorphic marker from GABRA3 gene." Am J Med Genet 60(5): 434-435.
|
| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
59 cases and 51 controls |
| SNP/Region/Marker Size |
1 STRs |
| Predominant Ethnicity |
Caucasian |
| Population |
Spainish |
| Gender |
24 males, 35 females in cases and 24 males, 27 females in controls |
| Age Group |
adults
:
Older than age 40 years
|
Detail Info
| Sample Diagnosis |
DSM-III-R, RDC |
| Sample Status |
We have studied a total of 51 normal controls and 59 unrelated patients diagnosed as bipolar I (43 subjects) or bipolar II (16 subjects) according to DSM-111-R and RDC. 28 of those patients presented a familiar history of psychiatric illness, considering this like the presence of at least one affected first-degree relative. |
| Technique |
PCR and electrophoresis |
| Statistical Method |
chi-square tests |
| Result Summary |
Statistic studies using X2did not reveal any allele to be more frequent in the MD population. Similar negative results have been obtained when we compared allele frequencies between controls and the different affected subpopulations. Thus, the present study does not reveal an association between GAJ3RA3 gene and MD in this Spanish population. |
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| GABRA3 (AC)n |
GABRA3 |
duplication |
|
|
chi square tests:all P-value >0.05
|
No evidence support the association of this variant with BD
No evidence support the association of this variant with BD
|
Negative
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| GABRA3 |
We have not found significant differences between controls and patients in allele frequencies or gen......
We have not found significant differences between controls and patients in allele frequencies or genotypes
More...
|
Negative
|
