Study Report
Basic Info
| Reference |
Massat, I.,2002(a) PMID: 11840313
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| Citation |
Massat, I., D. Souery, et al. (2002). "Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study." Mol Psychiatry 7(2): 201-207.
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| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
185 BPAD patients and 370 controls |
| SNP/Region/Marker Size |
1 variant |
| Predominant Ethnicity |
Caucasian |
| Population |
European |
| Gender |
Male/female:69/116 for BPD patients and 138/232 for controls |
Detail Info
| Sample Diagnosis |
DSM and RDC |
| Sample Status |
The present sample has been recruited within the Biomedical European (BIOMED 1) European Collaborative Project on Affective Disorders (ECPAD)(European Community Grant CT92-1217, project leader J Mendlewicz) and BIOMED 2 (European Collaborative Study on Molecular Genetics in Affective Disorders, Contract No: BMH4-CT-97-2307).A total of 555 subjects were recruited, including 185 BPAD patients, each matched with two controls (n = 370) for sex and ethnogeographical origin. |
| Technique |
genotyping |
| Statistical Method |
Conditional logistic regression by the GENEPOP,3.d program-updated version of GENEPOP |
| Result Summary |
A significant increase of genotype 1-1 was observed in BPAD females compared to controls (P=0.0004). Furthermore, when considering recessivity of allele 1 (females with genotype 1-1 and males carrying allele 1), results were even more significant (P= 0.00002). Our findings suggest that the GABRA3 polymorphism may confer susceptibility to or may be in linkage disequilibrium with another gene involved in the genetic etiology of BPAD. |
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| GABRA3 CA repeat |
GABRA3 |
microsatellite |
multi-allelic repeats |
|
Association analysis:Conditional logistic regression, genotype 1-1, BPAD females compared to controls, P-value = 0.0004;females with genotype 1-1 and males carrying allele 1, P-value = 0.00002
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Significant associations were found in BPD patients.
Significant associations were found in BPD patients.
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Positive
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Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| GABRA3 |
Our findings suggest that the GABRA3 polymorphism may confer susceptibility to or may be in linkage ......
Our findings suggest that the GABRA3 polymorphism may confer susceptibility to or may be in linkage disequilibrium with another gene involved in the genetic etiology of BPAD.
More...
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Positive
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