SNP Report

Basic Info

Name	rs12912251 dbSNP Ensembl
Location	chr15:38694167 - 38694167(1)
Variant Alleles	G/T
Ancestral Allele	G
Minor Allele	T
Minor Allele Frequence	0.183706
Functional Annotation	downstream_gene_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000560203); upstream_gene_variant(ENST00000318792)
No. of Studies	2 (Positive: 0; Negative: 0; Trend: 2)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Green, E. K.,2012	G/T		BD ImmunoChip:P-value = 0.029,OR = 1.125;ImmunoChip, PGC-BD ...... BD ImmunoChip:P-value = 0.029,OR = 1.125;ImmunoChip, PGC-BD combined data:P-balue = 0.000000294,OR = 1.103 More...	Suggestive association was found. Suggestive association was found.	Trend
Sklar, P.,2011	G/T		Primary GWAS P-value(GC)=0.00000957, OR=1.13; replication P-...... Primary GWAS P-value(GC)=0.00000957, OR=1.13; replication P-value(1-sided)=0.0204, OR=1.06; Combined GWAS and replication P-value(GC)=0.00000327, OR=1.1 More...	Suggestive association was found. Suggestive association was found.	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
C15orf53	chromosome 15 open reading frame 53	15q14	3(0/1/2)

SNPs in LD with rs12912251 (count: 10) View in gBrowse (chr15:38694167..38707193 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs7171233	upstream_gene_variant	1.0[CEU]
rs12898460	upstream_gene_variant	1.0[CEU]
rs12901215	downstream_gene_variant	1.0[CEU]
rs7165988	missense_variant; synonymous_variant	1.0[CEU]
rs7177621		0.933[CEU]; 0.944[TSI]
rs12916379	3_prime_UTR_variant	1.0[CEU]; 0.945[TSI]
rs7183893	downstream_gene_variant	0.812[CEU]
rs12903120	upstream_gene_variant	1.0[CEU]; 1.0[TSI]
rs2132157	downstream_gene_variant	1.0[CEU]; 0.945[TSI]
rs7163869	upstream_gene_variant	1.0[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)