Study Report

Basic Info

Reference	Kranz, T. M.,2012 PMID: 22944046
Citation	Kranz, T. M., S. Ekawardhani, et al. (2012). "The chromosome 15q14 locus for bipolar disorder and schizophrenia: Is C15orf53 a major candidate gene?" J Psychiatr Res 46(11): 1414-1420.
Disease Type	Bipolar Disorder & Schizophrenia & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	individuals affected by BD and/or SCZD10 (n = 274) and controls (n = 230)
SNP/Region/Marker Size	3 SNPs
Predominant Ethnicity	Caucasian
Population	German
Age Group	adults : Mean age of patients was 46,SD = 15 years, of controls 32,SD = 10.5 years.

Detail Info

Sample Diagnosis	DSM
Technique	Genotyping
Statistical Method	chi-square tests
Result Summary	C15orf53 revealed no mutations in our SCZD10 family members, but segregation of two common haplotypes was found. No association of identified haplotypes was found in our case-control samples. Gene expression could be demonstrated for immune-system-derived cells but not for the post-mortem human limbic brain tissue. Our results indicate that C15orf53 is probably neither causative for the etiology of BD nor for SCZD10 in our samples.

Genetic factors reported by this study for BD

Haplotypes reported by this study for BD (count: 2)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs7171233 - rs7165988 - rs2172835	A-G-T	C15orf53	CHI SQUARE = 1.164,P-value = 0.2806	No significant association was observed. No significant association was observed.	Negative
rs7171233 - rs7165988 - rs2172835	T-C-C	C15orf53	CHI SQUARE = 1.546,P-value = 0.2137	No significant association was observed. No significant association was observed.	Negative

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
C15orf53	Our results indicate that C15orf53 is probably neither causative for the etiology of BD nor for SCZD...... Our results indicate that C15orf53 is probably neither causative for the etiology of BD nor for SCZD10 in our samples. More...	Negative

Genetic factors reported by this study for SZ and/or MDD

Haplotypes reported by this study for SZ/MDD

Disease	Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Description	Result Category
SZ	rs7171233 - rs7165988 - rs2172835	T-C-C	C15orf53	CHI SQUARE = 1.077,P-value = 0.2993	No significant association was observed.	Negative
SZ	rs7171233 - rs7165988 - rs2172835	A-G-T	C15orf53	CHI SQUARE = 0.206,P-value = 0.6502	No significant association was observed.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	C15orf53	Our results indicate that C15orf53 is probably neither causative for the etiology of BD nor for SCZD10 in our samples.	Negative