BDgene

Study Report

Basic Info
Reference
Citation Kajio, Y., et al. (2014). "Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population." J Hum Genet 59(1): 54-56.
Disease Type Bipolar Disorder & Schizophrenia
Study Design case-control
Study Type Candidate-gene association study
Sample Size 1032 SCZ and 1012 BD patients, and 993 controls; BD type I=621, BD type II=380, schizoaffective disorder (SA)=7, unknown type of diagnosis=4
SNP/Region/Marker Size 37 SNPs
Predominant Ethnicity Mongloid
Population Japanese
Gender 48.3% female for SCZ patients; 51.8%(1012) female of BD patients; 51.1%(993) female of healthy controls.
Age Group adults : mean age (SD) = 46.8 (14.8) years for SCZ patients; mean age (SD) = 50.7 (14.3) years for BD patients; mean age (SD) = 49.7 (14.0) years for controls.

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 5)

Genes reported by this study for BD (count: 5)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs243021 BCL11A P-value=0.12, Pcorrected=1, OR=0.89 for SZ in screening stage, P-value=0.59, OR=1.03 for replication. No association was found for SZ. Negative
SZ rs7178572 HMG20A P-value=0.25, Pcorrected=1, OR=0.93 for SZ in screening stage, P-value=0.28, OR=1.05 for replication. No association was found for SZ. Negative
SZ rs4812829 HNF4A P-value=0.281, Pcorrected=1.0, OR=0.93 for SZ in screening stage, P-value=0.49, OR=1.03 for replication. No association was found for SZ. Negative
SZ rs7612463 UBE2E2 P-value=0.021, Pcorrected=0.68, OR=1.23 for SZ in screening stage. In the SCZ sample, only one SNP in UBE2E2 (rs7612463) showed a nominal significant association (Puncorrected < 0.05). Positive
SZ rs3802177 SLC30A8 P-value=0.95, Pcorrected=1, OR=1.00 for SZ in screening stage. No association was found for SZ. Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ UBE2E2 In the SCZ sample, only one SNP in UBE2E2 (rs7612463) showed a nominal significant association (Puncorrected<0.05) Positive
SZ HNF4A No association was found for SNPs in this gene for SZ. Negative
SZ HMG20A No association was found for SNPs in this gene for SZ. Negative
SZ BCL11A No association was found for SNPs in this gene for SZ. Negative
SZ SLC30A8 No association was found for SNPs in this gene for SZ. Negative