BDgene

Study Report

Basic Info
Reference
Citation Kushima, I., B. Aleksic, et al. (2010). "Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population." J Hum Genet 55(3): 133-136.
Disease Type Bipolar Disorder & Schizophrenia
Study Design case-control
Study Type Candidate-gene association study
Sample Size For the bipolar disorder study, 867 cases and 895 age- and gender-matched controls were used.For the schizophrenia study, 715 cases and age and gender-matched 711 controls were used.
SNP/Region/Marker Size 7 SNPs
Predominant Ethnicity Mongloid
Population Japanese
Age Group Adults : Mean age(SD)(year):50.7(14.2) in BD patients,49.9(13.5) in BD controls;47.5(14.0) in SZ patients,46.7(13.1) in SZ controls

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 7)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs6554557 USP46 Allele-/genotype wise analyses:X2 test, allele P-value > 0.05;genotype P-value > 0.05 No significant association was observed. Negative
SZ rs346005 USP46 Allele-/genotype wise analyses:X2 test, allele P-value > 0.05;genotype P-value > 0.05 No significant association was observed. Negative
SZ rs2244291 USP46 Allele-/genotype wise analyses:X2 test, allele P-value > 0.05;genotype P-value > 0.05 No significant association was observed. Negative
SZ rs17675844 USP46 Allele-/genotype wise analyses:X2 test, allele P-value > 0.05;genotype P-value > 0.05 No significant association was observed. Negative
SZ rs12646800 USP46 Allele-/genotype wise analyses:X2 test, allele P-value = 0.04, P-value > 0.05 after Bonferroni correction;genotype P-value = 0.01, P-value > 0.05 after Bonferroni correction. No significant association was observed. Negative
SZ rs10517263 USP46 Allele-/genotype wise analyses:X2 test, allele P-value > 0.05;genotype P-value > 0.05 No significant association was observed. Negative
SZ rs10034164 USP46 Allele-/genotype wise analyses:X2 test, allele P-value > 0.05;genotype P-value > 0.05 No significant association was observed. Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ USP46 In conclusion, our data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46. Negative