SNP Report

Basic Info

Name	rs4760820 dbSNP Ensembl
Location	chr12:72003216 - 72003216(1)
Variant Alleles	C/G
Ancestral Allele	C
Minor Allele	G
Minor Allele Frequence	0.178514
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000333850)
No. of Studies	4 (Positive: 2; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 4)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Cichon, S., 2008	C/G	G	Cochrane-Armitage trend test P-value = 0.3 in the German BPA...... Cochrane-Armitage trend test P-value = 0.3 in the German BPAD sample. Cochrane-Armitage trend test P-value = 0.49 in the Russian BPAD sample. Cochrane-Armitage trend test P-value = 0.48 in Combined German/Russian sample. More...		Positive
Grigoroiu-Serbanescu, M.,2008	C/G		Cochrane-Armitage trend test P value=0.145 Cochrane-Armitage trend test P value=0.145		Negative
Gao, J., 2016			Fixed effect model: P-value<0.0001,Â OR=0.7702, 95%CI=0.6882...... Fixed effect model: P-value<0.0001,Â OR=0.7702, 95%CI=0.6882-0.8618; Random effects model: P-value=0.0368,Â OR=0.6202, 95%CI=0.3961-0.9711; More...	The difference of allele frequency distribution of rs4760820...... The difference of allele frequency distribution of rs4760820 was compared between 1126 BD patients and 1721 controls in four studies. The between-study heterogeneity was statistically significant, so the summary OR of all ethnic groups was calculated at 0.62 with the random effective model, which again suggests an association of rs4760820 with BD. It appeared that rs11178998 and rs4760820 had strong epidemiological credibility, while rs7954758 had relatively weak association due to significant between-study heterogeneity and failure to reach statistical significance in the random effective model. More...	Positive
Campos, S. B., 2010				The allele and genotype distribution of all SNPs showed no d...... The allele and genotype distribution of all SNPs showed no differences between BD patients and controls. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
TPH2	tryptophan hydroxylase 2	12q15	13(10/3/0)

SNPs in LD with rs4760820 (count: 0) View in gBrowse (chr12:72003216..72003216 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)