BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Campos, S. B., 2010 PMID: 19800079
Citation	Campos, S. B., D. M. Miranda, et al. (2010). "Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior." J Psychiatr Res 44(5): 271-274.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	303 diagnosed with bipolar disorder and 224 healthy controls
SNP/Region/Marker Size	8 tagSNPs
Predominant Ethnicity	Caucasian
Population	Brazilian
Gender	70.95% (215) females in patients, 67.85% (152) females in controls.
Age Group	adult : mean age 41.43(SD=13.09), range 19-68 years for patients, mean age 49.77(SD=21.88), range 19-71 for controls.

Detail Info

SNPs reported by this study for BD (count: 8)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs7955501	TPH2				The allele and genotype distribution of all SNPs showed no d...... The allele and genotype distribution of all SNPs showed no differences between BD patients and controls. More...	Negative
rs10506645	TPH2				The allele and genotype distribution of all SNPs showed no d...... The allele and genotype distribution of all SNPs showed no differences between BD patients and controls. More...	Negative
rs10879357	TPH2				The allele and genotype distribution of all SNPs showed no d...... The allele and genotype distribution of all SNPs showed no differences between BD patients and controls. More...	Negative
rs11179000	TPH2				The allele and genotype distribution of all SNPs showed no d...... The allele and genotype distribution of all SNPs showed no differences between BD patients and controls. More...	Negative
rs1487275	TPH2				The allele and genotype distribution of all SNPs showed no d...... The allele and genotype distribution of all SNPs showed no differences between BD patients and controls. More...	Negative
rs4448731	TPH2				The allele and genotype distribution of all SNPs showed no d...... The allele and genotype distribution of all SNPs showed no differences between BD patients and controls. More...	Negative
rs4565946	TPH2				The allele and genotype distribution of all SNPs showed no d...... The allele and genotype distribution of all SNPs showed no differences between BD patients and controls. More...	Negative
rs4760820	TPH2				The allele and genotype distribution of all SNPs showed no d...... The allele and genotype distribution of all SNPs showed no differences between BD patients and controls. More...	Negative

Haplotypes reported by this study for BD (count: 3)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs7955501 - rs10506645 - rs4760820	ATC	TPH2	P-value = 0.05, OR = 4.117	The A-T-C haplotype was significantly more frequent in patie...... The A-T-C haplotype was significantly more frequent in patients with BD when compared with controls, but the result did not survive permutation testing. More...	Positive
rs4565946 - rs11179000 - rs7955501 - rs10506645	CATT	TPH2	P-value = 0.03, OR = 2.162e-007	The C-A-T-T haplotype was significantly more frequent in pat...... The C-A-T-T haplotype was significantly more frequent in patients with BD when compared with controls, but the result did not survive permutation testing. More...	Positive
rs4448731 - rs4565946 - rs11179000	CCT	TPH2	P-value = 0.05; OR = 5.224e-008	The C-C-T haplotype occurred only in controls. But the resul...... The C-C-T haplotype occurred only in controls. But the result did not survive permutation testing. More...	Positive

Genes reported by this study for BD (count: 1)