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Study Report
| Comment on Study | View All Comments on Study |
Basic Info
| Reference | Roche, S.,2009 PMID: 19352219 |
|---|---|
| Citation | Roche, S. and P. McKeon (2009). Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder. Psychiatr Genet 19(3): 142-146. |
| Disease Type | Bipolar Disorder |
| Study Design | family-based |
| Study Type | Candidate-gene association study |
| Sample Size | 151 BPAD type I trios |
| SNP/Region/Marker Size | 13 SNPs |
| Predominant Ethnicity | Caucasian |
| Population | Irish |
Detail Info
| Sample Diagnosis | DSM and SCID |
|---|---|
| Sample Status | All trios are of Irish descent and were diagnosed based on the Diagnostic and Statistical Manual of Mental Disorders,fourth edition (DSM-IV) criteria and using information gained from hospital records and semistructured interviews conducted using the Schedule of Affective Disorders and Schizophrenia (Lifetime version; SADS-LB) or Structured Clinical Interview for DSM-IV Axis I Disorders: Clinical Version (SCID-CV) interview schedules. |
| Technique | genotyping |
| Statistical Method | Transmission Disequilibrium Test (TDT) |
| Result Summary | SNPs rs1386482 and rs1386486, which are in very strong linkage disequilibrium, were associated with BPAD (P=0.006). The association retained significance after a correction for multiple testing. The associated SNPs are in perfect linkage disequilibrium with SNPs previously associated with BPAD (rs4290270) and impulsivity (rs1386483), a core trait of BPAD. These results strongly support a role for TPH2 in the aetiology of BPAD. |
| SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|---|
| rs6582078 | TPH2 | G | TDT: X2=1.829, P-value = 0.1762 | No significant association was observed No significant association was observed | Negative | |
| rs9325202 | TPH2 | A | TDT: X2=1.199, P-value = 0.2736 | No significant association was observed No significant association was observed | Negative | |
| rs1007023 | TPH2 | G | TDT: X2=0.053, P-value = 0.8185 | No significant association was observed No significant association was observed | Negative | |
| rs1352250 | TPH2 | A | TDT: X2=1.939, P-value = 0.1637 | No significant association was observed No significant association was observed | Negative | |
| rs10506645 | TPH2 | T | TDT: X2=1, P-value = 0.3173 | No significant association was observed No significant association was observed | Negative | |
| rs1386486 | TPH2 | T | TDT: X2=7.336, P-value = 0.0068 | Significant association was observed Significant association was observed | Positive | |
| rs1386482 | TPH2 | A | TDT: X2=7.538, P-value = 0.006 | Significant association was observed Significant association was observed | Positive | |
| rs1386493 | TPH2 | T | TDT: X2=1.389, P-value = 0.2386 | No significant association was observed No significant association was observed | Negative | |
| rs1386491 | TPH2 | G | TDT: X2=1.175, P-value = 0.2784 | No significant association was observed No significant association was observed | Negative | |
| rs1843809 | TPH2 | G | TDT: X2=0.222, P-value = 0.6374 | No significant association was observed No significant association was observed | Negative | |
| rs1487275 | TPH2 | G | TDT: X2=2.571, P-value = 0.1088 | No significant association was observed No significant association was observed | Negative | |
| rs2171363 | TPH2 | T | TDT: X2=2.945, P-value = 0.0861 | No significant association was observed No significant association was observed | Negative | |
| rs2129575 | TPH2 | T | TDT: X2=3.108, P-value = 0.0779 | No significant association was observed No significant association was observed | Negative |
| Markers | Haplotype | Related Gene(s)/Region(s) | Statistical Values | Author Comments | Result Category |
|---|---|---|---|---|---|
| rs1352250 - rs9325202 | A-A | TPH2 | haplotype:X<sup>2</sup>=1.574, Individual P-value =0.2097 | No significant association was found . No significant association was found . | Negative |
| rs1487275 - rs1386486 - rs1386482 | G-T-A | TPH2 | haplotype:X<sup>2</sup>=2.829, Individual P-value =0.0926 | No significant association was found . No significant association was found . | Negative |
| rs1487275 - rs1386486 - rs1386482 | T-C-C | TPH2 | haplotype:X<sup>2</sup>=5.607, Individual P-value =0.0179 | Significant association was found. Significant association was found. | Positive |
| rs1352250 - rs9325202 | A-G | TPH2 | haplotype:X<sup>2</sup>=0.967, Individual P-value =0.3255 | No significant association was found . No significant association was found . | Negative |
| rs1352250 - rs9325202 | G-G | TPH2 | haplotype:X<sup>2</sup>=2.099, Individual P-value =0.1474 | No significant association was found . No significant association was found . | Negative |
| rs1843809 - rs1386493 - rs2171363 - rs1386491 - rs6582078 - rs10506645 - rs1007023 | G-T-T-C-G-C-G | TPH2 | haplotype:X<sup>2</sup>=0.329, Individual P-value =0.5663 | No significant association was found . No significant association was found . | Negative |
| rs1487275 - rs1386486 - rs1386482 | T-T-A | TPH2 | haplotype:X<sup>2</sup>=2.522, Individual P-value =0.1122 | No significant association was found . No significant association was found . | Negative |
| rs1843809 - rs1386493 - rs2171363 - rs1386491 - rs6582078 - rs10506645 - rs1007023 | T-C-T-G-G-T-T | TPH2 | haplotype:X<sup>2</sup>=1.393, Individual P-value =0.2379 | No significant association was found . No significant association was found . | Negative |
| rs1843809 - rs1386493 - rs2171363 - rs1386491 - rs6582078 - rs10506645 - rs1007023 | T-C-C-C-T-C-T | TPH2 | haplotype:X<sup>2</sup>=1.95, Individual P-value =0.1626 | No significant association was found . No significant association was found . | Negative |
| rs1843809 - rs1386493 - rs2171363 - rs1386491 - rs6582078 - rs10506645 - rs1007023 | T-T-T-C-G-C-T | TPH2 | haplotype:X<sup>2</sup>=0.667, Individual P-value =0.4142 | No significant association was found . No significant association was found . | Negative |
| Gene | Statistical Values/Author Comments | Result Category |
|---|---|---|
| TPH2 | These results strongly support a role for TPH2 in the aetiology of BPAD. These results strongly support a role for TPH2 in the aetiology of BPAD. | Positive |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: March 31, 2016