Bipolar disorder (BD) is a common psychiatric disease with estimated heritability ranging from 80%-85%. Meanwhile, BD shares several key clinical features and familial determinants with schizophrenia (SZ) and major depressive disorder (MDD). It is of vital importance to study the genetic basis of BD and the shared genetic factors with its highly relevant diseases. BDgene was developed to address the genetic complexity of BD and its overlap with SZ and MDD. By profound literature screening, BDgene integrates not only multi-type BD-related genetic factors (e.g. SNP, CNV, gene, pathway), but also overlapping genetic factors between BD and SZ/MDD, which presents a panoramic view of current genetic studies for BD. Based on the literature data, in-depth analyses were conducted to help understand the data and data connections, and to provide new hypothesis for new scientific findings.
Citation: Chang, S. H., Gao, L., Li, Z., Zhang, W. N., Du, Y., & Wang, J. (2013). BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder. Biol Psychiatry. doi: 10.1016/j.biopsych.2013.04.016 Link
- BD genetic factors
- BD-SZ-MDD shared genetic factors
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