SNP Report

Basic Info

Name	rs744731 dbSNP Ensembl
Location	chr4:17491220 - 17491220(1)
Variant Alleles	T/C
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.198882
Functional Annotation	intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000281243, ENST00000428702, ENST00000501943, ENST00000505710, ENST00000507439, ENST00000508623, ENST00000511609, ENST00000513615, ENST00000514300); NMD_transcript_variant(ENST00000507439, ENST00000514300); non_coding_transcript_variant(ENST00000501943, ENST00000511609)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Shi, J., 2008 (b)	A/G	G	Allelic association of neurotransmission systems genes with ...... Allelic association of neurotransmission systems genes with bipolar disorder: TDT P-value = 0.0055, Gene-wide P-value = 0.014 (P values were based on permutation for all SNPs in each gene). More...	rs744731 in the QDPR gene reached gene-wide association. Non...... rs744731 in the QDPR gene reached gene-wide association. None of these associations survived multiple testing for its own system (e.g., glutamatergic or serotoninergic) or all the five systems taken together. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
QDPR	quinoid dihydropteridine reductase	4p15.31	1(1/0/0)

SNPs in LD with rs744731 (count: 2) View in gBrowse (chr4:17491220..17502216 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs10516314		intron_variant; NMD_transcript_variant	1.0[CEU]
rs3796809		intron_variant; NMD_transcript_variant	1.0[CEU]; 1.0[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)