BDgene

SNP Report

Basic Info
Name rs744731 dbSNP Ensembl
Location chr4:17491220 - 17491220(1)
Variant Alleles T/C
Ancestral Allele T
Minor Allele C
Minor Allele Frequence 0.198882
Functional Annotation intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript intron_variant(ENST00000281243, ENST00000428702, ENST00000501943, ENST00000505710, ENST00000507439, ENST00000508623, ENST00000511609, ENST00000513615, ENST00000514300); NMD_transcript_variant(ENST00000507439, ENST00000514300); non_coding_transcript_variant(ENST00000501943, ENST00000511609)
No. of Studies 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Shi, J., 2008 (b) A/G G Allelic association of neurotransmission systems genes with ...... Allelic association of neurotransmission systems genes with bipolar disorder: TDT P-value = 0.0055, Gene-wide P-value = 0.014 (P values were based on permutation for all SNPs in each gene). More... rs744731 in the QDPR gene reached gene-wide association. Non...... rs744731 in the QDPR gene reached gene-wide association. None of these associations survived multiple testing for its own system (e.g., glutamatergic or serotoninergic) or all the five systems taken together. More... Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
QDPR quinoid dihydropteridine reductase 4p15.31 1(1/0/0)

SNPs in LD with rs744731 (count: 2) View in gBrowse (chr4:17491220..17502216 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 2)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)