BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Austin, J.,2000 PMID: 10909129
Citation	Austin, J., B. Hoogendoorn, et al. (2000). "Association analysis of the proneurotensin gene and bipolar disorder." Psychiatr Genet 10(1): 51-54.
Disease Type	Bipolar I Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	219 bipolar probands and 219 control probands
SNP/Region/Marker Size	3 variants
Predominant Ethnicity	Caucasian
Population	British
Gender	42% male
Age Group	Adults : Mean age(SD)(year):45.7(13.3) in BD probands and 44.0(9.7) for controls in main association sample ;50(43) in BD probands and 48(18) for controls in replication sample

Detail Info

Sample Diagnosis	DSM
Sample Status	All subjects were Caucasians born in the UK or Eire.The main association sample were recruited from psychiatric outpatient clinics in England and Wales.Fifty-eight subjects had a family history of affective disorder in a first degree relative.Controls were group matched for age,sex and ethnicity from more than 700 blood donors recruited from the local branch of the National Blood Transfusion Service(Wales).In order to further investigate findings exceeding conventional levels of ststistical significance,we used a repliacation sample comprising a further 105 probans recuited from psychiatric out-patient clinics in England and Wales and 110 comparison individuals who were attending a family medical practitioner in South Wales for non-psychiatric reasons.
Replication Size	105 bipolar probands and 110 control probands
Technique	PCR and DHPLC
Statistical Method	X² test
Result Summary	These have now been tested for association with bipolar disorder using a case-control sample of unrelated bipolar subjects and matched controls. No evidence for association was found, and our data therefore suggest that sequence variation in this gene does not make an important contribution to susceptibility to bipolar disorder.

Haplotypes reported by this study for BD (count: 1)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
(NTS_3A>G) - (NTS_166C>G)		NTS	Haplotypic association:X<sup>2</sup> =1.96; df=3; P-value = 0.58	No significant association was found . No significant association was found .	Negative

Other variants reported by this study for BD (count: 2)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
NTS 3A>G	NTS	point mutation	A>G		Association analysis:allele, X² = 0.51; df=1; P-value = 0.48;genotype, X² = 6.17; df=2; P-value = 0.046, in full samples, X² = 4.43; df=2; P-value = 0.11	Significant associations were found in genotypic frequencies...... Significant associations were found in genotypic frequencies. More...	Positive
NTS 166C>G	NTS	point mutation	C>G		Association analysis:allele, X² = 0.89; df=1; P-value = 0.35;genotype, X² = 0.93; df=2; P-value = 0.63	No significant association was observed. No significant association was observed.	Negative

Genes reported by this study for BD (count: 1)