Study Report

Basic Info

Reference	Pae, C. U., 2007 (b) PMID: 17644186
Citation	Pae, C. U., S. J. Yoon, et al. (2007). "Quinone oxidoreductase (NQO1) gene polymorphism may not confer a susceptibility to mood disorders." Psychiatry Res 153(1): 83-86.
Disease Type	Bipolar I Disorder & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	80 patients with BID, 61 patients with MDD and 106 controls
SNP/Region/Marker Size	1 SNP
Predominant Ethnicity	Mongloid
Population	Korean
Gender	39.3% male MDD patients, 51.3% male BID patients, 48.1% male controls
Age Group	adults : mean age=47.1 (SD=15.3) years for MDD patients, mean age=34.4 (SD=12.7) years for BID patients, mean age=33.8 (SD=11.5) years for controls

Detail Info

Sample Diagnosis	Structured Clinical Interview, DSM-IV Axis I disorders-Clinical Version (SCID-I-CV)
Sample Status	Subjects comprised 80 patients with BID and 61 patients with MDD. The family history, history of suicide attempts and psychotic episodes, and age at onset were all ascertained when the subject underwent psychiatric evaluation and treatment. Subjects with neurological and current medico-surgical illnesses such as endocrine and autoimmune disease were excluded from the study.
Technique	genotyping using PCR-based methods
Statistical Method	Comparisons of the NQO1 genotype and allele distributions were made using a chi-square test. The continuous variables were analyzed using a Mann-Whitney test. The genotypic associations were evaluated by logistic regression, with an adjustment for age and gender. Monte Carlo methods were employed to assess the contingency table, with small cell counts in subgroup analyses. All the tests were carried out with a nominal two-tailed significance level of 5%.
Result Summary	These preliminary results showed that the NQO1 gene polymorphism was not related to a susceptibility to mood disorders.

Genetic factors reported by this study for BD

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
NQO1 C609T	NQO1	point mutation	C/T		chi-square test, genotypic P-value = 0.598, X²=1.027, allelic P-value = 0.353, X²=0.862 in BID patients; genotypic P-value = 0.558, X²=1.158, allelic P-value = 0.460, X²=0.545 in MDD and BID patients	There were no differences in the distribution of the genotyp...... There were no differences in the distribution of the genotypes and alleles of the NQO1 C609T polymorphism between the BID patients and the controls. The combined analysis of the MDD and BID patients did not reveal any significant association between the genotypes and allele distributions of the patients and controls. More...	Negative

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
NQO1	The NQO1 gene polymorphism was not related to a susceptibility to mood disorders (BD and MDD). The NQO1 gene polymorphism was not related to a susceptibility to mood disorders (BD and MDD).	Negative

Genetic factors reported by this study for SZ and/or MDD

Other variants reported by this study for SZ/MDD

Disease	Variant Name	Related Gene	Type	Statistical Values	Description	Result Category
MDD	NQO1 C609T	NQO1	point mutation	chi-square test, genotypic P-value = 0.458, X²=1.561, allelic P-value = 0.808, X²=0.059 in the MDD patients; genotypic P-value = 0.558, X²=1.158, allelic P-value = 0.460, X²=0.545 in MDD and BID patients	There were no differences in the distribution of the genotypes and alleles of the NQO1 C609T polymorphism between the MDD patients and the controls. The combined analysis of the MDD and BID patients did not reveal any significant association between the genotypes and allele distributions of the patients and controls.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
MDD	NQO1	The NQO1 gene polymorphism was not related to a susceptibility to mood disorders (BD and MDD).	Negative