Gene Report

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Basic Info

Approved Symbol	NNMT
Approved Name	nicotinamide N-methyltransferase
Location	11q23.1
Position	chr11:114257787-114313285, 1
External Links	HGNC: 7861 Entrez Gene: 4837 Ensembl: ENSG00000166741 UCSC: uc001pos.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Sazci, A., 2013	SNP: rs694539	Here we report the association of the rs694539 variant of nicotinamide-N-methyltransferase gene with bipolar disorder.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0010243	response to organonitrogen compound	biological process	IEA	1
GO:0008112	nicotinamide N-methyltransferase activity	molecular function	IEA	1
GO:0042493	response to drug	biological process	IEA	57
GO:0031100	organ regeneration	biological process	IEA	5
GO:0032259	methylation	biological process	TAS	6
GO:0005829	cytosol	cellular component	TAS	223
GO:0006805	xenobiotic metabolic process	biological process	TAS	19

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00760	Nicotinate and nicotinamide metabolism	3

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs694539	chr11:114262697 - 114262697(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
11q22.3-11q23	chr11:102900000-121200000	2 (0/2/0)
Chr 11	chr11:0-135086622	2 (0/2/0)
11q22-q23	chr11:97200000-121200000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr11:114257787..114313285 View in gBrowse