BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Sazci, A., 2013 PMID: 24004542
Citation	Sazci, A., M. D. Ozel, et al. (2013). "Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder." Gene.
Disease Type	bipolar disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	95 bipolar disorder patients and 201 healthy controls
SNP/Region/Marker Size	1 SNP
Predominant Ethnicity
Population	Turkish
Age Group	adults : patients: 38.35, SD=11.690 years, with an age range of 21-75 years; controls: an average age of 36.42, SD=11.514, ranging from 17 to 72 years of age

Detail Info

Sample Diagnosis	DMS-IV
Sample Status	All subjects were recruited from the University of Kocaeli Hospital, Psychiatry clinic and diagnosis of the bipolar patients was based on DMS-IV criteria.
Technique	genotyping
Statistical Method	The Hardy-Weinberg equilibrium was verified for both groups. Allele and genotype frequencies were compared using the _2 test. The relative risk as odds ratio (OR) was determined using 2 _ 2 crosstabulation and a binary logistic regression model for age and gender. Differences between groupswere examined using _2 test and Student's _-test. All statistical analyses were performed using SPSS software package version 21.0. The P-value < 0.05 was considered statistically significant.
Result Summary	Here we report the association of the rs694539 variant of nicotinamide-N-methyltransferase gene with bipolar disorder in a case-control study of 95 bipolar disorder patients and 201 healthy controls (chi2=13.382, P=0.001). With the polymerase chain reaction restriction fragment length polymorphism method we developed we were able to show the association for the first time. This new finding may provide evidence to understand the mechanism of the disease.

SNPs reported by this study for BD (count: 1)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs694539	NNMT	G/A		P-value=0.001, X²=13.382; P-value=0.001, X²=11.981, OR; 95% CI=0.414 (0.250-0.686) for GG genotype; , P-value=0.003, X²=8.777, OR; 95% CI=2.141 (1.288-3.559) for GA genotype; P-value=0.067, X²=3.359, OR; 95% CI=4.374 (0.787-24.313) for AA genotype; P-value=0.067, X²=3.359, OR; 95% CI=0.229 (0.041-1.271) for G allele; P-value=0.001, X²=11.981, OR; 95% CI=2.414 (1.457-4.000) for A allele	rs694539 variant of NNMT gene is associated with bipolar dis...... rs694539 variant of NNMT gene is associated with bipolar disorders; Although the individuals with GG genotype showed protection towards bipolar disorders, the individuals with GA genotype had a 2.141-fold increased risk for bipolar disorders; Moreover the A allele showed statistically significant association with bipolar disorders. More...	Positive

Genes reported by this study for BD (count: 1)