BDgene

Study Report

Basic Info
Reference
Citation Kimura, H., et al. (2014). "Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility." Schizophr Bull.
Disease Type Bipolar Disorder & Schizophrenia
Study Design case-control
Study Type Candidate-gene association study
Sample Size cases: 3554 SZ and 1041 BD; controls: 4746 controls
SNP/Region/Marker Size 3 variants
Predominant Ethnicity Mongloid
Population Japanese
Age Group adult : cases: SCZ mean=48.4, SD=14.6; BD mean=51.0, SD=14.1. controls: mean=43.2, SD=14.7.

Detail Info

Genetic factors reported by this study for BD
Other variants reported by this study for BD (count: 3)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
Other variants reported by this study for SZ/MDD
Disease Variant Name Related Gene Type Statistical Values Description Result Category
SZ NDE1 Chr16:15785033 C/G NDE1 missense SZ: MAF=0.0015, P-value=0.15, OR=0.65 No significant association was observed. Negative
SZ NDE1 Chr16:15785118 C/T NDE1 missense SZ: MAF=0.00076, P-value=0.039, OR=7.1 We observed a signifiant association between SCZ and this variant. Positive
SZ NDE1 Chr16:15785177 C/T NDE1 missense SZ: MAF=0.00013, P-value=0.46 No significant association was observed. Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ NDE1 This study strengthens the evidence for association between rare variants within NDE1 and SCZ, and may shed light into the molecular mechanisms underlying this severe psychiatric disorder. Positive