Study Report
Basic Info
| Reference |
Piccardi, M. P.,2002 PMID: 11901356
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| Citation |
Piccardi, M. P., R. Ardau, et al. (2002). "Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes." Psychiatr Genet 12(1): 23-27.
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| Disease Type |
Bipolar Disorder |
| Study Design |
family-based |
| Study Type |
Candidate-gene association study |
| Sample Size |
101 probands |
| SNP/Region/Marker Size |
2 variants |
| Predominant Ethnicity |
Caucasian |
| Population |
Italian |
| Gender |
46 male, 55 female |
| Age Group |
Adults
:
Mean age at onset(SD)(year):22.6(6.5)
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Detail Info
| Sample Diagnosis |
RDC |
| Sample Status |
Probands were identified from among outpatients attending the Center of Clinical Psychopharmacology of the Department of Neurosciences, University of Cagliari and, in order to increase the sample size,from those referred by psychiatrists working in public or private facilities in Sardinia. Probands were eligible if they met Research Diagnostic Criteria(RDC) for bipolar disorder (Spitzer et al., 1977), had both biological parents available, and were of Sardinian ancestry (four Sardinian grandparents). |
| Technique |
PCR and RFLP |
| Statistical Method |
The difference of transmission of the alleles in proband/parent trios was analyzed using the transmission disequilibrium test (TDT) (Spielman et al.,1993). |
| Result Summary |
In our trios sample, the transmission disequilibrium test revealed no preferential transmission of alleles of the 5-HTTLPR and INPP1 from heterozygous parents to probands. Therefore, additional family-based data are warranted, possibly with a more complete subdivision of 5-HTTLPR alleles, since short and long alleles have recently been divided into four and six kinds of allelic variant, respectively, with significant ethnic differences in allele and genotype distributions. |
Other variants reported by this study for BD (count: 2)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| 5HTTLPR |
SLC6A4 |
microsatellite |
short/long |
|
Association analysis:TDT, allele long, T/NT=56/47, chi square=0.78, P-value = 0.37
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No significant association was observed in BD.
No significant association was observed in BD.
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Negative
|
| INPP1 C973A |
INPP1 |
point mutation |
C973A |
|
Association analysis:TDT, allele C, T/NT=29/23, chi square=0.96, P-value = 0.33
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No significant association was observed in BD.
No significant association was observed in BD.
|
Negative
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Genes reported by this study for BD (count: 2)
| Gene |
Statistical Values/Author Comments |
Result Category |
| SLC6A4 |
In our trios sample, the transmission disequilibrium test revealed no preferential transmission of a......
In our trios sample, the transmission disequilibrium test revealed no preferential transmission of alleles of the 5-HTTLPR from heterozygous parents to probands.
More...
|
Negative
|
| INPP1 |
In our trios sample, the transmission disequilibrium test revealed no preferential transmission of a......
In our trios sample, the transmission disequilibrium test revealed no preferential transmission of alleles of the INPP1 from heterozygous parents to probands.
More...
|
Negative
|
