Study Report

Basic Info
Reference |
Ewald, H.,1995 PMID: 8750358
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Citation |
Ewald, H., O. Mors, et al. (1995). "No evidence of linkage between manic depressive illness and the dopa decarboxylase gene or nearby region on chromosome 7p." Psychiatr Genet 5(4): 161-169.
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Disease Type |
Bipolar Disorder |
Study Design |
family-based |
Study Type |
Linkage study |
Sample Size |
2 families |
SNP/Region/Marker Size |
11 microsatellite polymorphisms |
Predominant Ethnicity |
Caucasian |
Population |
Danish |

Detail Info
Sample Diagnosis |
RDC |
Sample Status |
Families were identified through bipolar probands in contact with the Psychiatric Hospital in Aarhus, Denmark. Two large families with multiple affected members over several generations without evidence of bilineal transmission were included in the study. No one in the blood line was nosed as having schizophrenia, schizoaffective disorder, or any type of psychosis other than manic depressive disorder. |
Technique |
Southern blot and DNA hybridization |
Statistical Method |
Linkage analyses were undertaken by calculating lod scores using the computer program LINKAGE |
Result Summary |
The DDC marker was only informative in family 4, for dominant models 2 and 3 the lod scores were below -2 at zero recombination fraction ,no evidence of linkage to DDC was found; Close linkage to markers D7S526, D7S484, D7S691, D7S670, D7S506, D7S473 and D7S672 was excluded for the two families combined for all dominant models, and to D7S510 for dominant models 2 and 3. The highest lod score found was 1.37 for marker D7S528; D7S485 yielded a lod score of 1.29 at 0.10 recombination fraction for dominant model in family 4. In total, no evidence of linkage was found assuming a dominant or recessive model of inheritance. |

Other variants reported by this study for BD (count: 1)
Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
DDC microsatellite polymorphisms |
DDC |
microsatellite |
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for dominant models 2 and 3 the lod scores were below -2 at zero recombination fraction
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No evidence support the association of this variant with BD
No evidence support the association of this variant with BD
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Negative
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Genes reported by this study for BD (count: 1)
Gene |
Statistical Values/Author Comments |
Result Category |
DDC |
For dominant models 2 and 3 the lod scores were below -2 at zero recombination fraction.
No evidence of linkage to DDC was found
No evidence of linkage to DDC was found
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Negative
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Regions reported by this study for BD (count: 1)
Region |
Statistical Values |
Author Comments |
Result Category |
7p11-p13 |
The DDC marker was only informative in family 4, for dominant models 2 and 3 the lod scores were below -2 at zero recombination fraction; Close linkage to markers D7S526, D7S484, D7S691, D7S670, D7S506, D7S473 and D7S672 was excluded for the two families combined for all dominant models, and to D7S510 for dominant models 2 and 3. The highest lod score found was 1.37 for marker D7S528; D7S485 yielded a lod score of 1.29 at 0.10 recombination fraction for dominant model in family 4.
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No evidence of linkage was found assuming a dominant or rece......
No evidence of linkage was found assuming a dominant or recessive model of inheritance.
More...
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Negative
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