BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Ewald, H.,1995 PMID: 8750358
Citation	Ewald, H., O. Mors, et al. (1995). "No evidence of linkage between manic depressive illness and the dopa decarboxylase gene or nearby region on chromosome 7p." Psychiatr Genet 5(4): 161-169.
Disease Type	Bipolar Disorder
Study Design	family-based
Study Type	Linkage study
Sample Size	2 families
SNP/Region/Marker Size	11 microsatellite polymorphisms
Predominant Ethnicity	Caucasian
Population	Danish

Detail Info

Sample Diagnosis	RDC
Sample Status	Families were identified through bipolar probands in contact with the Psychiatric Hospital in Aarhus, Denmark. Two large families with multiple affected members over several generations without evidence of bilineal transmission were included in the study. No one in the blood line was nosed as having schizophrenia, schizoaffective disorder, or any type of psychosis other than manic depressive disorder.
Technique	Southern blot and DNA hybridization
Statistical Method	Linkage analyses were undertaken by calculating lod scores using the computer program LINKAGE
Result Summary	The DDC marker was only informative in family 4, for dominant models 2 and 3 the lod scores were below -2 at zero recombination fraction ,no evidence of linkage to DDC was found; Close linkage to markers D7S526, D7S484, D7S691, D7S670, D7S506, D7S473 and D7S672 was excluded for the two families combined for all dominant models, and to D7S510 for dominant models 2 and 3. The highest lod score found was 1.37 for marker D7S528; D7S485 yielded a lod score of 1.29 at 0.10 recombination fraction for dominant model in family 4. In total, no evidence of linkage was found assuming a dominant or recessive model of inheritance.

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
DDC microsatellite polymorphisms	DDC	microsatellite			for dominant models 2 and 3 the lod scores were below -2 at zero recombination fraction	No evidence support the association of this variant with BD No evidence support the association of this variant with BD	Negative

Genes reported by this study for BD (count: 1)

Regions reported by this study for BD (count: 1)

Region	Statistical Values	Author Comments	Result Category
7p11-p13	The DDC marker was only informative in family 4, for dominant models 2 and 3 the lod scores were below -2 at zero recombination fraction; Close linkage to markers D7S526, D7S484, D7S691, D7S670, D7S506, D7S473 and D7S672 was excluded for the two families combined for all dominant models, and to D7S510 for dominant models 2 and 3. The highest lod score found was 1.37 for marker D7S528; D7S485 yielded a lod score of 1.29 at 0.10 recombination fraction for dominant model in family 4.	No evidence of linkage was found assuming a dominant or rece...... No evidence of linkage was found assuming a dominant or recessive model of inheritance. More...	Negative