Gene Report

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Basic Info

Approved Symbol	CPQ
Symbol Alias	LDP, PGCP
Approved Name	carboxypeptidase Q
Name Alias	lysosomal dipeptidase, "Ser-Met dipeptidase", "plasma glutamate carboxypeptidase"
Location	8q22.2
Position	chr8:96645227-97149654, 1
External Links	HGNC: 16910 Entrez Gene: 10404 Ensembl: ENSG00000104324 UCSC: uc003yhw.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Djurovic, S.,2010	SNP: rs11992953, rs7844514	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005764	lysosome	cellular component	ISS	16

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0070573	metallodipeptidase activity	molecular function	IDA[10206990]	1
GO:0042246	tissue regeneration	biological process	ISS	2
GO:0006508	proteolysis	biological process	IDA[10206990]	34
GO:0005794	Golgi apparatus	cellular component	ISS	60
GO:0043171	peptide catabolic process	biological process	IDA[10206990]	3
GO:0006590	thyroid hormone generation	biological process	ISS	3
GO:0005737	cytoplasm	cellular component	IDA[10206990]	322
GO:0042803	protein homodimerization activity	molecular function	IDA[12675526]	71
GO:0005615	extracellular space	cellular component	IDA[10206990]	85
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0005783	endoplasmic reticulum	cellular component	ISS	49
GO:0004180	carboxypeptidase activity	molecular function	IEA	3
GO:0046872	metal ion binding	molecular function	IEA	115

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 12)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11992953	chr8:97092405 - 97092405(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/1/0)
rs7844514	chr8:97117952 - 97117952(1)	intron_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs10955102	chr8:97100403 - 97100403(1)	intron_variant
rs12114373	chr8:97095222 - 97095222(1)	downstream_gene_variant; intron_variant
rs12114789	chr8:97097045 - 97097045(1)	downstream_gene_variant; intron_variant
rs10955101	chr8:97093865 - 97093865(1)	downstream_gene_variant; intron_variant
rs10098932	chr8:97094217 - 97094217(1)	downstream_gene_variant; intron_variant
rs11998215	chr8:97084675 - 97084675(1)	intron_variant; non_coding_transcript_variant
rs10955100	chr8:97091168 - 97091168(1)	intron_variant; non_coding_transcript_variant
rs13438930	chr8:97080484 - 97080484(1)	intron_variant; non_coding_transcript_variant
rs10955099	chr8:97081214 - 97081214(1)	intron_variant; non_coding_transcript_variant
rs13439480	chr8:97080309 - 97080309(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8q12.1-q22.1	chr8:54600000-97900000	1 (1/0/0)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr8:96645227..97149654 View in gBrowse