Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	CEP85L
Previous Symbol	C6orf204
Symbol Alias	NY-BR-15, bA57K17.2
Approved Name	centrosomal protein 85kDa-like
Previous Name	chromosome 6 open reading frame 204
Location	6q22.31
Position	chr6:118460772-118710075, -1
External Links	HGNC: 21638 Entrez Gene: 387119 Ensembl: ENSG00000111860 UCSC: uc003pya.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fan, J., 2010	SNP: rs12153828, rs2496353, rs3734381	For gene-based test, P-value = 0.036 in STEP2. nominally significant in STEP2 sample, but not survive Bonferroni correction test.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 2)

GO terms by PBA (count: 0)

GO terms by database search (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0005813	centrosome	cellular component	TAS[21399614]	34

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 44)

Literature-origin SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3734381	chr6:118566140 - 118566140(1)	missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(1/0/0)
rs2496353	chr6:118502372 - 118502372(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(1/0/0)
rs12153828	chr6:118659949 - 118659949(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)
rs794854	chr6:118711163 - 118711163(1)	upstream_gene_variant	1(1/0/0)

LD-proxies (count: 40)

rs_ID	Location	Functional Annotation
rs10457338	chr6:118462855 - 118462855(1)	3_prime_UTR_variant
rs12214483	chr6:118458983 - 118458983(1)	downstream_gene_variant; upstream_gene_variant
rs9372511	chr6:118711900 - 118711900(1)	upstream_gene_variant
rs12199463	chr6:118505532 - 118505532(1)	downstream_gene_variant; intron_variant
rs6925641	chr6:118500731 - 118500731(1)	intron_variant; upstream_gene_variant
rs11153752	chr6:118513608 - 118513608(1)	intron_variant
rs11755121	chr6:118506961 - 118506961(1)	downstream_gene_variant; intron_variant
rs2213856	chr6:118485630 - 118485630(1)	intron_variant
rs3798420	chr6:118465323 - 118465323(1)	3_prime_UTR_variant
rs12194555	chr6:118498049 - 118498049(1)	intron_variant; upstream_gene_variant
rs2356492	chr6:118488274 - 118488274(1)	downstream_gene_variant; intron_variant
rs544160	chr6:118583459 - 118583459(1)	intron_variant; non_coding_transcript_variant
rs503031	chr6:118555647 - 118555647(1)	intron_variant
rs2516262	chr6:118510295 - 118510295(1)	intron_variant
rs2496352	chr6:118498515 - 118498515(1)	intron_variant; upstream_gene_variant
rs7755056	chr6:118472984 - 118472984(1)	intron_variant
rs17080517	chr6:118711510 - 118711510(1)	upstream_gene_variant
rs9320664	chr6:118665065 - 118665065(1)	intron_variant; upstream_gene_variant
rs12210025	chr6:118662761 - 118662761(1)	intron_variant; non_coding_transcript_variant
rs12189855	chr6:118654058 - 118654058(1)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs6941759	chr6:118565134 - 118565134(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs12153955	chr6:118554522 - 118554522(1)	intron_variant
rs3752581	chr6:118548567 - 118548567(1)	intron_variant
rs13192336	chr6:118553999 - 118553999(1)	intron_variant
rs10484285	chr6:118635938 - 118635938(1)	intron_variant; non_coding_transcript_variant
rs973944	chr6:118529793 - 118529793(1)	intron_variant
rs579528	chr6:118599826 - 118599826(1)	intron_variant; non_coding_transcript_variant
rs12206329	chr6:118542626 - 118542626(1)	intron_variant
rs13220480	chr6:118595464 - 118595464(1)	intron_variant; non_coding_transcript_variant
rs12208253	chr6:118603934 - 118603934(1)	intron_variant; non_coding_transcript_variant
rs7751467	chr6:118572698 - 118572698(1)	intron_variant; non_coding_transcript_variant
rs11968351	chr6:118580346 - 118580346(1)	intron_variant; non_coding_transcript_variant
rs6902812	chr6:118615131 - 118615131(1)	intron_variant; non_coding_transcript_variant
rs12203311	chr6:118507780 - 118507780(1)	downstream_gene_variant; intron_variant
rs11153763	chr6:118617575 - 118617575(1)	intron_variant; non_coding_transcript_variant
rs7740645	chr6:118608045 - 118608045(1)	intron_variant; non_coding_transcript_variant
rs7769001	chr6:118613346 - 118613346(1)	intron_variant; non_coding_transcript_variant
rs2798321	chr6:118670439 - 118670439(1)	intron_variant
rs9320663	chr6:118665009 - 118665009(1)	intron_variant; upstream_gene_variant
rs9320665	chr6:118665146 - 118665146(1)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Zhang[2009]_142	chr6:119101408-119211399 (Affymetrix SNP 6.0 array reference genome)	109991		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q22.1-6q22.33	chr6:114200000-130000000	1 (0/1/0)
6q21-22	chr6:105000000-130000000	1 (0/0/1)
6q22	chr6:114200000-130000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr6:118460772..118710075 View in gBrowse