BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Dizier, M. H.,2012 PMID: 22628130
Citation	Dizier, M. H., B. Etain, et al. (2012). "Genetic heterogeneity according to age at onset in bipolar disorder: A combined positional cloning and candidate gene approach." Am J Med Genet B Neuropsychiatr Genet.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	443 BD patients and 1,731 control subjects
SNP/Region/Marker Size	4 SNPs
Predominant Ethnicity	Caucasian
Population	French
Gender	187 males and 256 females in BD patients;712 males and 1,019 females in control subjects
Age Group	Adults

Detail Info

Sample Diagnosis	DSM
Sample Status	Bipolar sample. All participants had been included in a largescale ongoing study of the genetic determinants of BD. The sample comprised 443 BD patients who met the DSM-IV criteria for BD type I or II (American Psychiatric Association, 1994) and who were recruited through systematic screening of patients treated in the outpatient facilities of two university-affiliated psychiatric departments in France (Creteil and Bordeaux).Inclusion criteria were defined as being more than 18 years of age and of French descent. Control sample. A sample of 1,731 HC was provided by the Centre National de Genotypage (CNG; Evry, France).This sample was previously collected and genotyped for association and population studies. Permission to use it was obtained from the original investigators.
Replication Size	WTCCC samples:1,732 BD patients having a determined AAO and 2,938 controls
Technique	Genotyping
Statistical Method	SNP-by-SNP analyses consisted of classical single-marker association analyses performed using Fisher's exact test and PLINK software [Purcell et al., 2007].Gene-based analysis:Each gene was analyzed using the set-based test in PLINK.
Result Summary	We provide evidence for genetic heterogeneity within the ADRB2 (beta-2adrenoreceptor) gene region that is specifically associated with the early onset form of BD with an OR of 1.8. Unfortunately, the genotyping coverage of ADRB2 in the Wellcome Trust Case Control Consortium sample meant undermined our efforts to undertake a replication. However, as the ADRB2 gene product directly interacts with the CACNA1C gene product, and is known to be implicated in BD susceptibility, we conclude that further exploration of the relationships between ADRB2 and BD needs to be undertaken.

Genes reported by this study for BD (count: 1)