BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	XBP1 -116C>G
Type	point mutation
Related Gene	XBP1
No. of Study	3 (Positive: 1; Negative 2; Trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Variant related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Cichon, S., 2004	C>G		PDT tests P-value = 0.2 for NIMH Waves 1 and 2 complete, P-value = 0.79 for NIMH Wave 3, P-value = 0.86 for Bulgarian trios, P-value = 0.5 for UK trios.	Our results do not support a significant association of -116..... More Our results do not support a significant association of -116Câ†’G with BPAD in any of these four samples. Less	Negative
Kakiuchi, C.,2003	C>G		Association analysis:case-control study, genotype P-value = 0.00026(BPD), 0.0040(BP-I), 0.023(BP-II);allele P-value = 0.010(BPD), 0.081(BP-I), 0.015(BP-II);TDT for G allele, P-value = 0.047(BPD), 0.027(BP-I)	Significant associations were found in BPD patients.	Positive
Hou, S. J., 2004	C/G		Genotypic P-value = 0.674, allelic P-value = 0.436 for bipolar disorder; genotypic P-value = 0.176 for bipolar disorder with family history; genotypic P-value = 0.938 for bipolar disorder without family history	No association was demonstrated between this polymorphism an..... More No association was demonstrated between this polymorphism and family history in bipolar disorder patients. Less	Negative

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)