Study Report
Basic Info
| Reference |
Cichon, S., 2004 PMID: 15284840
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| Citation |
Cichon, S., S. Buervenich, et al. (2004). "Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin." Nat Genet 36(8): 783-784; author reply 784-785.
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| Disease Type |
Bipolar Disorder |
| Study Design |
family-based |
| Study Type |
Candidate-gene association study |
| Sample Size |
Four family-based BPAD samples comprising 586 families: (i) 147 families from the NIMH Genetics Initiative Waves 1 and 2, including the 88 trios studied by Kakiuchi et al.; (ii) 176 families from the NIMH Wave 3, identified in a similar manner as the earlier waves; (iii) 173 Bulgarian trios, identified through a proband having DSMIV bipolar I disorder (BPI); and (iv) 90 similarly identified UK parent-proband trios with DSMIV BPI. |
| SNP/Region/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian |
| Population |
European |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Statistical Method |
X2 with 1 degree of freedom. NIMH Waves 1, 2 and 3 were analyzed by PDT7, as not all trios were complete and multiple siblings per family were used to extract the maximal information. All other samples consist of complete trios and were analyzed by TDT. For PDT tests, test statistics and P values using the 'average' option are shown. |
| Result Summary |
Our results do not support a significant association of a functional promoter polymorphism of XBP1 (-116C_G) with BPAD in any of these four samples. |
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| XBP1 -116C>G |
XBP1 |
point mutation |
C>G |
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PDT tests P-value = 0.2 for NIMH Waves 1 and 2 complete, P-value = 0.79 for NIMH Wave 3, P-value = 0.86 for Bulgarian trios, P-value = 0.5 for UK trios.
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Our results do not support a significant association of -116......
Our results do not support a significant association of -116C→G with BPAD in any of these four samples.
More...
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Negative
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