BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	GSK3B -50T/C
Type	point mutation
Location	promoter
Related Gene	GSK3B
No. of Study	3 (Positive: 0; Negative 3; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Variant related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Nishiguchi, N., 2006	T/C		allelic P-value = 0.646, X²=0.265, d.f.=1, OR=0.9425 (95% CI 0.7524-1.181); genotypic P-value = 0.449, X²=1.609, d.f.=2	There was no difference in the allele and genotype frequenci..... More There was no difference in the allele and genotype frequencies of the -50T/C between the bipolar disorders and the controls. Less	Negative
Lee, K. Y., 2006 (b)	C/T		allelic P-value = 0.45, genotypic P-value = 0.55 for BD patients, allelic P-value = 0.62, genotypic P-value = 0.53 for BD and SZ patients	Whether allele- or genotype-wise, no evidence of association..... More Whether allele- or genotype-wise, no evidence of association with either samples of schizophrenia and bipolar disorder could be detected. Same results were obtained when the combined samples of schizophrenia and bipolar disorder were compared to healthy controls. When the samples were compared by each sex, there was also no evidence of association between patients and controls. Less	Negative
Lee, Y. J.,2011	50C/T		chi-squared test:genotype, X²=1.55, P-value = 0.461;allele, X²=1.09, P-value = 0.297	No significant association was observed.	Negative

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Lee, K. Y., 2006 (b)	allelic P-value = 0.94, genotypic P-value = 0.76 for SZ patients, allelic P-value = 0.62, genotypic P-value = 0.53 for BD and SZ patients	Whether allele- or genotype-wise, no evidence of association with either samples of schizophrenia and bipolar disorder could be detected. Same results were obtained when the combined samples of schizophrenia and bipolar disorder were compared to healthy controls. When the samples were compared by each sex, there was also no evidence of association between patients and controls.	Negative

Overlap with MDD from cross-disorder studies (count: 0)