BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Wen, Z., 2016 PMID: 26888291
Citation	Wen, Z., et al. (2016). "Genetic association between NRG1 and schizophrenia, major depressive disorder, bipolar disorder in Han Chinese population." Am J Med Genet B Neuropsychiatr Genet 171(3): 468-478.
Disease Type	major depressive disorder & Bipolar Disorder & Schizophrenia
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	1,248 schizophrenia cases, 1,056 major depression cases, 1,344 bipolar disorder cases, and 1,248 controls
SNP/Region/Marker Size	15 SNPs
Predominant Ethnicity	Han Chinese
Population	Shanghai in origin
Gender	845 males and 403 females for schizophrenia cases, 737 males and 319 females for major depressive disorder cases, 584 males and 760 females for bipolar disorder cases, 672 males and 576 females for normal controls
Age Group	adults : mean age (SD) = 36.44(9.00) years for schizophrenia cases; mean age (SD) = 34.41(12.09) years for major depressive disorder cases; mean age (SD) = 38.84 (11.44) years for bipolar disorder cases, mean age (SD) = 30.62 (11.35) years for normal controls

Detail Info

SNPs reported by this study for BD (count: 5)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs4512342	NRG1	G/T		P-value=0.803,Â OR=1.015, 95%CI=0.904-1.139	We also identified association between rs2439281, rs11989919...... We also identified association between rs2439281, rs11989919, rs7829383, rs2919375, rs4512342, and bipolar disorder before Bonferroni correction, but no association remained after the correction. More...	Negative
rs2919375	NRG1	C/T		P-value=0.051,Â OR=1.117, 95%CI=0.999-1.249	We also identified association between rs2439281, rs11989919...... We also identified association between rs2439281, rs11989919, rs7829383, rs2919375, rs4512342, and bipolar disorder before Bonferroni correction, but no association remained after the correction. More...	Negative
rs2439281	NRG1	A/G		P-value=0.027,Â OR=1.170, 95%CI=1.018-1.345	We also identified association between rs2439281, rs11989919...... We also identified association between rs2439281, rs11989919, rs7829383, rs2919375, rs4512342, and bipolar disorder before Bonferroni correction, but no association remained after the correction. More...	Positive
rs7829383	NRG1	A/G		P-value=0.006,Â OR=0.858, 95%CI=0.769-0.957	We also identified association between rs2439281, rs11989919...... We also identified association between rs2439281, rs11989919, rs7829383, rs2919375, rs4512342, and bipolar disorder before Bonferroni correction, but no association remained after the correction. More...	Positive
rs11989919	NRG1	C/T		P-value=0.040,Â OR=0.891, 95%CI=0.798-0.994	We also identified association between rs2439281, rs11989919...... We also identified association between rs2439281, rs11989919, rs7829383, rs2919375, rs4512342, and bipolar disorder before Bonferroni correction, but no association remained after the correction. More...	Positive

Haplotypes reported by this study for BD (count: 2)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs4512342-rs6982890	T-T	NRG1	P(unadj)-value=0.019, Bonferroni P-value=0.057, OR=1.183, 95%CI=1.026-1.364	In rs4512342-rs6982890, there was no significant results for...... In rs4512342-rs6982890, there was no significant results for bipolar disorder after Bonferroni correction. More...	Negative
rs4531002-rs11989919	C-T	NRG1	P(unadj)-value=0.001,Â Bonferroni P-value=0.003, OR=1.211, 95%CI=1.076-1.363	In the block rs4531002-rs11989919, haplotype, CT, proved to ...... In the block rs4531002-rs11989919, haplotype, CT, proved to be a risk factor of bipolar disorder, and global. More...	Positive